Disease detection with molecular biomarkers: from chemistry of body fluids to nature-inspired chemical sensors

YY Broza, X Zhou, M Yuan, D Qu, Y Zheng… - Chemical …, 2019 - ACS Publications
This article aims to review nature-inspired chemical sensors for enabling fast, relatively
inexpensive, and minimally (or non-) invasive diagnostics and follow-up of the health …

The extended granin family: structure, function, and biomedical implications

A Bartolomucci, R Possenti, SK Mahata… - Endocrine …, 2011 - academic.oup.com
The chromogranins (chromogranin A and chromogranin B), secretogranins (secretogranin II
and secretogranin III), and additional related proteins (7B2, NESP55, proSAAS, and VGF) …

Human body fluid proteome analysis

S Hu, JA Loo, DT Wong - Proteomics, 2006 - Wiley Online Library
The focus of this article is to review the recent advances in proteome analysis of human
body fluids, including plasma/serum, urine, cerebrospinal fluid, saliva, bronchoalveolar …

Proteomic studies of potential cerebrospinal fluid protein markers for Alzheimer's disease

M Puchades, SF Hansson, CL Nilsson… - Molecular brain …, 2003 - Elsevier
By comparing the cerebrospinal fluid (CSF) proteome between Alzheimer's disease (AD)
patients and controls, it may be possible to identify proteins that play a role in the disease …

Biomarker discovery and development for frontotemporal dementia and amyotrophic lateral sclerosis

JS Katzeff, F Bright, K Phan, JJ Kril, LM Ittner… - Brain, 2022 - academic.oup.com
Frontotemporal dementia refers to a group of neurodegenerative disorders characterized by
behaviour and language alterations and focal brain atrophy. Amyotrophic lateral sclerosis is …

[HTML][HTML] Identification and validation of novel cerebrospinal fluid biomarkers for staging early Alzheimer's disease

RJ Perrin, R Craig-Schapiro, JP Malone, AR Shah… - PloS one, 2011 - journals.plos.org
Background Ideally, disease modifying therapies for Alzheimer disease (AD) will be applied
during the 'preclinical'stage (pathology present with cognition intact) before severe neuronal …

[HTML][HTML] Synaptic proteomics reveal distinct molecular signatures of cognitive change and C9ORF72 repeat expansion in the human ALS cortex

ZI Laszlo, N Hindley, A Sanchez Avila, RA Kline… - Acta neuropathologica …, 2022 - Springer
Increasing evidence suggests synaptic dysfunction is a central and possibly triggering factor
in Amyotrophic Lateral Sclerosis (ALS). Despite this, we still know very little about the …

[HTML][HTML] Proteomics approaches for biomarker and drug target discovery in ALS and FTD

TJ Hedl, R San Gil, F Cheng, SL Rayner… - Frontiers in …, 2019 - frontiersin.org
Neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS) and
frontotemporal dementia (FTD) are increasing in prevalence but lack targeted therapeutics …

Comparative proteomics of cerebrospinal fluid in neuropathologically-confirmed Alzheimer's disease and non-demented elderly subjects

EM Castaño, AE Roher, CL Esh, TA Kokjohn… - Neurological …, 2006 - Taylor & Francis
Objectives: Diagnostic tests able to reveal Alzheimer's disease (AD) in living patients before
cognitive ability is destroyed are urgently needed. Such tests must distinguish AD from other …

Blood and plasma-based proteomic biomarker research in Alzheimer's disease

S Lista, F Faltraco, D Prvulovic, H Hampel - Progress in neurobiology, 2013 - Elsevier
Alzheimer's disease (AD) is the most important cause of dementia in the elderly. The
molecular alterations preceding this neurodegenerative pathology may take place even 20 …