Targeting oxidative stress in disease: promise and limitations of antioxidant therapy

HJ Forman, H Zhang - Nature Reviews Drug Discovery, 2021 - nature.com
Oxidative stress is a component of many diseases, including atherosclerosis, chronic
obstructive pulmonary disease, Alzheimer disease and cancer. Although numerous small …

Astrocytes in human central nervous system diseases: a frontier for new therapies

A Verkhratsky, A Butt, B Li, P Illes, R Zorec… - … and Targeted Therapy, 2023 - nature.com
Astroglia are a broad class of neural parenchymal cells primarily dedicated to homoeostasis
and defence of the central nervous system (CNS). Astroglia contribute to the …

Astrocyte energy and neurotransmitter metabolism in Alzheimer's disease: integration of the glutamate/GABA-glutamine cycle

JV Andersen, A Schousboe, A Verkhratsky - Progress in neurobiology, 2022 - Elsevier
Astrocytes contribute to the complex cellular pathology of Alzheimer's disease (AD).
Neurons and astrocytes function in close collaboration through neurotransmitter recycling …

Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease

DA Butterfield, B Halliwell - Nature Reviews Neuroscience, 2019 - nature.com
Alzheimer disease (AD) is a major cause of age-related dementia. We do not fully
understand AD aetiology and pathogenesis, but oxidative damage is a key component. The …

[HTML][HTML] Oxidative stress and the amyloid beta peptide in Alzheimer's disease

C Cheignon, M Tomas, D Bonnefont-Rousselot… - Redox biology, 2018 - Elsevier
Oxidative stress is known to play an important role in the pathogenesis of a number of
diseases. In particular, it is linked to the etiology of Alzheimer's disease (AD), an age-related …

Oxidative damage in neurodegeneration: roles in the pathogenesis and progression of Alzheimer disease

M Perluigi, F Di Domenico… - Physiological …, 2024 - journals.physiology.org
Alzheimer disease (AD) is associated with multiple etiologies and pathological mechanisms,
among which oxidative stress (OS) appears as a major determinant. Intriguingly, OS arises …

Mitochondria as potential targets in Alzheimer disease therapy: an update

G Cenini, W Voos - Frontiers in pharmacology, 2019 - frontiersin.org
Alzheimer disease (AD) is a progressive and deleterious neurodegenerative disorder that
affects mostly the elderly population. At the moment, no effective treatments are available in …

Oxidative stress, amyloid-β peptide, and altered key molecular pathways in the pathogenesis and progression of Alzheimer's disease

DA Butterfield, D Boyd-Kimball - Journal of Alzheimer's …, 2018 - content.iospress.com
Oxidative stress is implicated in the pathogenesis and progression of Alzheimer's disease
(AD) and its earlier stage, amnestic mild cognitive impairment (aMCI). One source of …

[HTML][HTML] Mitochondrial dysfunction and oxidative stress in aging and cancer

AV Kudryavtseva, GS Krasnov, AA Dmitriev… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Aging and cancer are the most important issues to research. The population in the world is
growing older, and the incidence of cancer increases with age. There is no doubt about the …

[HTML][HTML] Iron dyshomeostasis, lipid peroxidation and perturbed expression of cystine/glutamate antiporter in Alzheimer's disease: Evidence of ferroptosis

A Ashraf, J Jeandriens, HG Parkes, PW So - Redox biology, 2020 - Elsevier
Iron dyshomeostasis is implicated in Alzheimer's disease (AD) alongside β-amyloid and tau
pathologies. Despite the recent discovery of ferroptosis, an iron-dependent form cell death …