Prodrugs are bioreversible derivatives of drug molecules that undergo an enzymatic and/or
chemical transformation in vivo to release the active parent drug, which can then exert the …

ACE inhibitors have achieved widespread usage in the treatment of cardiovascular and
renal disease. ACE inhibitors alter the balance between the vasoconstrictive, salt-retentive …

Biomedical knowledge graphs (KGs), which can help with the understanding of complex
biological systems and pathologies, have begun to play a critical role in medical practice …

▪ Objective: To review available information on cough and angioneurotic edema associated
with angiotensin-converting enzyme (ACE) inhibitors.▪ Data Sources: All relevant articles …

Many drugs are administered at sites that are remote from their site of action. The most
common route of drug delivery is the oral route. The optimal physicochemical properties to …

Hypertension is a major risk factor for cardiovascular diseases such as stroke, myocardial
infarction, and heart failure, the leading causes of death in the Western world. Inhibitors of …

Benzoic acid esters of various substituted 2‐hydroxyacetamides (glycolamides) were found
to be hydrolyzed extremely rapidly in human plasma solutions, the half‐lives of hydrolysis …

A direct alkoxycarbonylation/cyclization reaction is accomplished under visible light-induced
photoredox catalysis. With this approach, a variety of ester-substituted indolo [2, 1-a] …

Objectives: Identify the mechanism of action of ACE inhibitors. Summarize monitoring/follow-
up for patients initiated on ACE inhibitor therapy. Review the dosing parameters adjusting or …

Renin is the main determinant of angiotensin (Ang) II levels. It, therefore, always appeared
desirable to reduce Ang II levels by direct inhibition of renin. So far, specific renin inhibitors …