NPM1-mutated acute myeloid leukemia: from bench to bedside
The nucleophosmin (NPM1) gene encodes for a multifunctional protein with prominent
nucleolar localization that shuttles between nucleus and cytoplasm. NPM1 mutations …
nucleolar localization that shuttles between nucleus and cytoplasm. NPM1 mutations …
The nuclear export protein XPO1—from biology to targeted therapy
AS Azmi, MH Uddin, RM Mohammad - Nature reviews Clinical oncology, 2021 - nature.com
Abstract Exportin 1 (XPO1), also known as chromosome region maintenance protein 1,
plays a crucial role in maintaining cellular homeostasis via the regulated export of a range of …
plays a crucial role in maintaining cellular homeostasis via the regulated export of a range of …
Mutant NPM1 directly regulates oncogenic transcription in acute myeloid leukemia
HJ Uckelmann, EL Haarer, R Takeda, EM Wong… - Cancer discovery, 2023 - AACR
The dysregulation of developmental and stem cell–associated genes is a common
phenomenon during cancer development. Around half of patients with acute myeloid …
phenomenon during cancer development. Around half of patients with acute myeloid …
[HTML][HTML] Decitabine-and 5-azacytidine resistance emerges from adaptive responses of the pyrimidine metabolism network
Mechanisms-of-resistance to decitabine and 5-azacytidine, mainstay treatments for myeloid
malignancies, require investigation and countermeasures. Both are nucleoside analog pro …
malignancies, require investigation and countermeasures. Both are nucleoside analog pro …
Mutant NPM1 hijacks transcriptional hubs to maintain pathogenic gene programs in acute myeloid leukemia
Nucleophosmin (NPM1) is a ubiquitously expressed nucleolar protein with a wide range of
biological functions. In 30% of acute myeloid leukemia (AML), the terminal exon of NPM1 is …
biological functions. In 30% of acute myeloid leukemia (AML), the terminal exon of NPM1 is …
Chronic interleukin-1 exposure triggers selection for Cebpa-knockout multipotent hematopoietic progenitors
The early events that drive myeloid oncogenesis are not well understood. Most studies focus
on the cell-intrinsic genetic changes and how they impact cell fate decisions. We consider …
on the cell-intrinsic genetic changes and how they impact cell fate decisions. We consider …
A comprehensive review of genetic alterations and molecular targeted therapies for the implementation of personalized medicine in acute myeloid leukemia
Acute myeloid leukemia (AML) is an extremely heterogeneous disease defined by the clonal
growth of myeloblasts/promyelocytes not only in the bone marrow but also in peripheral …
growth of myeloblasts/promyelocytes not only in the bone marrow but also in peripheral …
Driver mutations in acute myeloid leukemia
A Kishtagari, RL Levine, AD Viny - Current opinion in hematology, 2020 - journals.lww.com
Driver mutations in acute myeloid leukemia : Current Opinion in Hematology Driver mutations
in acute myeloid leukemia : Current Opinion in Hematology Log in or Register Subscribe to …
in acute myeloid leukemia : Current Opinion in Hematology Log in or Register Subscribe to …
[HTML][HTML] Differentiation therapy and the mechanisms that terminate cancer cell proliferation without harming normal cells
FO Enane, Y Saunthararajah, M Korc - Cell death & disease, 2018 - nature.com
Chemotherapeutic drugs have a common intent to activate apoptosis in tumor cells.
However, master regulators of apoptosis (eg, p53, p16/CDKN2A) are frequently genetically …
However, master regulators of apoptosis (eg, p53, p16/CDKN2A) are frequently genetically …
[PDF][PDF] Interconversion between tumorigenic and differentiated states in acute myeloid leukemia
Tumors are composed of phenotypically heterogeneous cancer cells that often resemble
various differentiation states of their lineage of origin. Within this hierarchy, it is thought that …
various differentiation states of their lineage of origin. Within this hierarchy, it is thought that …