La LMA es una neoplasia hematológica que se caracteriza por la proliferación
descontrolada de progenitores mieloides que perdieron su capacidad de diferenciación. La …

Current murine xenotransplantation models used as in vivo study models of human
leukemic processes, particularly in acute myeloid leukemia (AML) have failed to reconstruct …

C-terminal mutation of Nucleophosmin 1 (NPM1 C+) was thought to be a primary driving
event in acute myeloid leukemia (AML) that reprograms leukemic-associated transcription …

Mechanisms-of-resistance to decitabine and 5-azacytidine, mainstay treatments for myeloid
malignancies, require investigation and countermeasures. Both are nucleoside analog pro …

Acute Myeloid Leukemia (AML) is a heterogeneous malignancy, characterized by impaired
differentiation towards the myeloid lineage and an increased self-renewal ability. One of the …

Acute myeloid leukaemia (AML) is an aggressive malignancy characterized by the
accumulation of transformed immature myeloid blasts. In recent years, genome wide …

Les leucémies aigües myéloïdes (LAM) constituent un groupe hétérogène d'hémopathies
malignes caractérisées par la prolifération clonale dans la moelle osseuse de précurseurs …

Mutations in isocitrate dehydrogenase 1 and 2 (IDH1/2) are found in 20-30% of adult acute
myeloid leukemia (AML). Wild type IDH1/2 produce α-ketoglutarate (αKG), an important co …

SPI1/PU. 1 est un facteur de transcription de la famille ETS, cette famille est caractérisée par
un domaine de fixation à l'ADN très conservé (domaine ETS) et un noyau de fixation …

NPM1-mutated acute myeloid leukemia (AML) represents the most frequent genetic subtype
of AML, accounting for about 30% to 35% of newly diagnosed cases in adults. 1 Because of …