Simple Summary Nucleophosmin (NPM) is one of the most abundant nucleolar proteins and
its mutations frequently occur in acute myeloid leukemia (AML). The mutations cause …

Simple Summary The appearance of a cell is connected to its function. For example, the
fusiform of smooth muscle cells is adapted to facilitate muscle contraction, the lobed nucleus …

Abstract DNA methyltransferase 1 (DNMT1) is scientifically validated as a molecular target to
treat chemo-resistant pancreatic ductal adenocarcinoma (PDAC). Results of clinical studies …

Somatic mutations in the nucleophosmin (NPM1) gene occur in approximately 30% of de
novo acute myeloid leukemias (AMLs) and are relatively enriched in normal karyotype …

ARID3C is a protein located on human chromosome 9 and expressed at low levels in
various organs, yet its biological function has not been elucidated. In this study, we …

BET inhibitors (BETi) including OTX015 (MK-8628) and JQ1 demonstrated antileukemic
activity including NPM1c AML cells. Nevertheless, the biological consequences of BETi in …

Simple Summary We describe the clinicopathologic features of eight patients with atypical
presentation of NPM1-mutated myeloid neoplasms (MN) and review the literature. Initially …

Nucleophosmin (NPM) mutations causing its export from the nucleoli to the cytoplasm are
frequent in acute myeloid leukemia (AML). Due to heterooligomerization of wild type NPM …

Nucleophosmin (NPM), one of the most abundant nucleolar proteins, has crucial functions in
ribosome biogenesis, cell cycle control, and DNA-damage repair. In human cells, NPM …

One mechanism by which lymphoid malignancies resist standard apoptosis-intending
(cytotoxic) treatments is genetic attenuation of the p53/p16-CDKN2A apoptosis axis …