The primary causes of chronic kidney disease (CKD) in children differ from those of CKD in
adults. In the USA the most common diagnostic groups of renal disease that manifest before …

As an integral member of the filtration barrier in the kidney glomerulus, the podocyte is in a
unique geographical position: It is exposed to chemical signals from the urinary space …

Steroid-resistant nephrotic syndrome (SRNS) is the second most frequent cause of ESRD in
the first two decades of life. Effective treatment is lacking. First insights into disease …

Cathepsins were originally identified as proteases that act in the lysosome. Recent work has
uncovered nontraditional roles for cathepsins in the extracellular space as well as in the …

The immunosuppressive action of the calcineurin inhibitor cyclosporine A (CsA) stems from
the inhibition of nuclear factor of activated T cells (NFAT) signaling in T cells. CsA is also …

Kidney disease affects over 20 million people in the United States alone. Although the
causes of renal failure are diverse, the glomerular filtration barrier is often the target of injury …

Progressive kidney failure is a genetically and clinically heterogeneous group of disorders.
Podocyte foot processes and the interposed glomerular slit diaphragm are essential …

Steroid-resistant nephrotic syndrome (SRNS) is a frequent cause of end-stage renal failure.
Identification of single-gene causes of SRNS has generated some insights into its …

The visceral glomerular epithelial cell, also called podocyte, is a terminally differentiated cell
that lines the outer aspect of the glomerular basement membrane (GBM). It therefore forms …

▪ Abstract Significant advances have been made in the application of genetics to probe the
functions of basement membrane laminins. These studies have shown that different laminin …