Targeting macrophage migration inhibitory factor in acute pancreatitis and pancreatic cancer

Y Wen, W Cai, J Yang, X Fu, L Putha, Q Xia… - Frontiers in …, 2021 - frontiersin.org
Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine implicated in the
pathogenesis of inflammation and cancer. It is produced by various cells and circulating MIF …

The role of CD74 in cardiovascular disease

QL Li, J Tang, L Zhao, A Ruze, XF Shan… - Frontiers in …, 2023 - frontiersin.org
Leukocyte differentiation antigen 74 (CD74), also known as invariant chain, is a molecular
chaperone of major histocompatibility complex class II (MHC II) molecules involved in …

Macrophage migration inhibitor factor (MIF): potential role in cognitive impairment disorders

L Zeng, P Hu, Y Zhang, M Li, S Li, A Luo - Cytokine & Growth Factor …, 2024 - Elsevier
Macrophage migration inhibitory factor (MIF) is a cytokine in the immune system,
participated in both innate and adaptive immune responses. Except from immune cells, MIF …

Sleep loss potentiates Th17‐cell pathogenicity and promotes autoimmune uveitis

X Liu, Y Su, Z Huang, J Lv, C Gu, Z Li… - Clinical and …, 2023 - Wiley Online Library
Background Sleep loss (SL) is a health issue associated with the higher risk of autoimmune
and inflammatory disorders. However, the connection between SL, the immune system, and …

Chronic inflammation, cancer development and immunotherapy

Y Wen, Y Zhu, C Zhang, X Yang, Y Gao, M Li… - Frontiers in …, 2022 - frontiersin.org
Chronic inflammation plays a pivotal role in cancer development. Cancer cells interact with
adjacent cellular components (pro-inflammatory cells, intrinsic immune cells, stromal cells …

The role of MIF in chronic lung diseases: looking beyond inflammation

L Florez-Sampedro, A Soto-Gamez… - … of Physiology-Lung …, 2020 - journals.physiology.org
Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that has been
associated with many diseases. Most studies found in literature describe MIF as a …

The role of macrophage migration inhibitory factor in alzheimer′ s disease: conventionally pathogenetic or unconventionally protective?

MC Petralia, G Battaglia, V Bruno, M Pennisi… - Molecules, 2020 - mdpi.com
Recent preclinical and clinical observations have offered relevant insights on the
etiopathogenesis of late onset Alzheimer′ s disease (AD) and upregulated …

Smoking shifts human small airway epithelium club cells toward a lesser differentiated population

MR Rostami, MG LeBlanc, Y Strulovici-Barel… - NPJ Genomic …, 2021 - nature.com
The club cell, a small airway epithelial (SAE) cell, plays a central role in human lung host
defense. We hypothesized that subpopulations of club cells with distinct functions may exist …

Exercise inhibits JNK pathway activation and lipotoxicity via macrophage migration inhibitory factor in nonalcoholic fatty liver disease

N Cui, H Li, Y Dun, JW Ripley-Gonzalez… - Frontiers in …, 2022 - frontiersin.org
The macrophage migration inhibitory factor (MIF) expressed in hepatocytes can limit
steatosis during obesity. Lipotoxicity in nonalcoholic fatty liver disease is mediated in part by …

Macrophage migration inhibitory factor (MIF) and its homolog D-dopachrome tautomerase (D-DT) are significant promotors of UVB-but not chemically induced non …

S Huth, L Huth, R Heise, Y Marquardt, L Lopopolo… - Scientific Reports, 2023 - nature.com
Non-melanoma skin cancer (NMSC) is the most common cancer in Caucasians worldwide.
We investigated the pathophysiological role of MIF and its homolog D-DT in UVB-and …