Small molecules and short peptides that potently and selectively bind RNA are rare, making
the molecular structures of these complexes highly exceptional. Accordingly, several recent …

Epitranscriptomic regulation controls information flow through the central dogma and
provides unique opportunities for manipulating cells at the RNA level. However, both …

Viruses remain a global threat to animals, plants, and humans. The type 1 human
immunodeficiency virus (HIV-1) is a member of the retrovirus family and carries an RNA …

Diversification of RNA-targeted scaffolds offers great promise in the search for selective
ligands of therapeutically relevant RNA such as HIV-1 TAR. We herein report the …

RNA-protein interfaces control key replication events during the HIV-1 life cycle. The viral
trans-activator of transcription (Tat) protein uses an archetypal arginine-rich motif (ARM) to …

Natural and lab-evolved proteins often recognize their RNA partners with exquisite affinity.
Structural analysis of such complexes can offer valuable insight into sequence-selective …

Human immunodeficiency virus-1 (HIV-1) transactivator (Tat)-mediated transcription is
essential for HIV-1 replication. It is determined by the interaction between Tat and …

The conserved and structured elements in viral RNA genomes interact with proteins to
regulate various events in the viral life cycle and have become key targets for developing …

DNA and RNA play pivotal roles in life processes by storing and transferring genetic
information, modulating gene expression, and contributing to essential cellular machinery …

Being able to effectively target RNA with potent ligands will open up a large number of
potential therapeutic options. The knowledge on how to achieve this is ever expanding but …