The hypothalamus‐pituitary‐thyroid (HPT) axis determines the set point of thyroid hormone
(TH) production. Hypothalamic thyrotropin‐releasing hormone (TRH) stimulates the …

The anterior pituitary gland integrates the repertoire of hormonal signals controlling thyroid,
adrenal, reproductive, and growth functions. The gland responds to complex central and …

Hypogonadotropic hypogonadism is defined as a deficiency of the pituitary secretion of
follicle-stimulating hormone and luteinizing hormone, which results in the impairment of …

Objective: The aim was to update The Endocrine Society Clinical Practice Guideline on
Evaluation and Treatment of Adult Growth Hormone Deficiency (GHD) previously published …

The transcription factor SOX2 is expressed most notably in the developing CNS and
placodes, where it plays critical roles in embryogenesis. Heterozygous de novo mutations in …

Thyrotropin-secreting pituitary adenomas (TSHomas) are a rare cause of hyperthyroidism
and account for less than 2% of all pituitary adenomas. In the last years, the diagnosis has …

Objective: The objective is to provide guidelines for the evaluation and treatment of adults
with GH deficiency (GHD). Participants: The chair of the Task Force was selected by the …

Duplications of Xq26-27 have been implicated in the etiology of X-linked hypopituitarism
associated with mental retardation (MR). Additionally, an expansion of a polyalanine tract …

The pituitary gland is an important component of the endocrine system, and together with the
hypothalamus, exerts considerable influence over the functions of other endocrine glands …

Tpit is a highly cell-restricted transcription factor that is required for expression of the pro-
opiomelanocortin (POMC) gene and for terminal differentiation of the pituitary corticotroph …