During its fourth transporter workshop in 2021, the International Transporter Consortium
(ITC) provided updates on emerging clinically relevant transporters for drug development …

The organic anion transporting polypeptide 2B1 (OATP2B1) was one of the first cloned
members of the SLCO family. However, its physiological and pharmacological role is still …

Abstract Background and Purpose Coproporphyrin (CP) I and III are byproducts of haem
synthesis currently investigated as biomarkers for drug–drug interactions involving hepatic …

Some drug molecules with strong chemical activity are unstable in the biological
environment and difficult to reach the target, so no matter how good the drug is, it cannot …

Failure to recognize important features of a drug's pharmacokinetic characteristics is a key
cause of inappropriate dose and schedule selection, and can lead to reduced efficacy and …

Human organic anion transporting polypeptide 2B1 (OATP2B1) is a membrane transporter
widely expressed in organs crucial for drug absorption and disposition such as the intestine …

Organic anion transporting polypeptide 2B1 (OATP2B1, gene SLCO2B1) is an uptake
transporter that is thought to determine drug disposition and in particular, the oral absorption …

Organic anion-transporting polypeptide (OATP) 1A2 and OATP2B1 mediate the intestinal
absorption of drugs. This study aimed to identify fruit juices or fruit juice components that …

Organic anion transporting polypeptide 2B1 (OATP2B1/SLCO2B1) facilitates uptake
transport of structurally diverse endogenous and exogenous compounds. To investigate the …

Chicoric acid (CA), an active phenolic acid of Echinacea purpurea (Linn.) Moench, has been
demonstrated to exhibit antioxidative, antiviral and immunological activities. A prior study …