Depression is a common mental disorder characterized by heterogeneous cognitive and
behavioral symptoms. The emerging research paradigm of functional connectomics has …

Importance The relative efficacy of ketamine and electroconvulsive therapy (ECT) in adults
with major depressive episode (MDE) needs clarification. Objective To compare depression …

Background Electroconvulsive therapy (ECT) and subanesthetic intravenous ketamine are
both currently used for treatment-resistant major depression, but the comparative …

Treatment‐resistant depression (TRD) is common and associated with multiple serious
public health implications. A consensus definition of TRD with demonstrated predictive utility …

The discovery of ketamine as a rapid-acting antidepressant led to a new era in the
development of neuropsychiatric therapeutics, one characterized by an antidepressant …

We have known for nearly a century that triggering seizures can treat serious mental illness,
but what we do not know is why. Electroconvulsive Therapy (ECT) works faster and better …

Background A significant proportion of adults with major depressive disorder (MDD) do not
respond to treatments which are currently used in clinical practice such as first-generation …

Background Intravenous racemic ketamine is a promising treatment for treatment-resistant
depression. However, its clinical utility compared with intranasal esketamine and the other …

Many drugs used in medicine have on-and off-label indications that span different medical
disciplines. Ketamine now has evidence of efficacy for emergency …

This Viewpoint examines key issues stemming from severalrecentreportsofelectroconvulsivether…
(ECT) vs ketamine infusion for improving depressive symptoms in treatment-resistant …