The discovery of leptin was intrinsically associated with its ability to regulate body weight.
However, the effects of leptin are more far-reaching and include profound glucose-lowering …

Accumulated evidence from genetic animal models suggests that the brain, particularly the
hypothalamus, has a key role in the homeostatic regulation of energy and glucose …

Leptin acts in the brain to prevent obesity. The underlying neurocircuitry responsible for this
is poorly understood, in part because of incomplete knowledge regarding first-order, leptin …

Interactions between the brain and distinct adipose depots have a key role in maintaining
energy balance, thereby promoting survival in response to metabolic challenges such as …

Abstract The “metabolic syndrome”(MetS) is a clustering of components that reflect
overnutrition, sedentary lifestyles, and resultant excess adiposity. The MetS includes the …

Although it is a widely held thought that direct hormone action on peripheral tissues is
sufficient to mediate the control of nutrient handling, the role of the central nervous system in …

Over the past two centuries, prevalent models of energy and glucose homeostasis have
emerged from careful anatomical descriptions in tandem with an understanding of cellular …

Background The hormone leptin is an important regulator of metabolic homeostasis, able to
inhibit food intake and increase energy expenditure. Leptin can also independently lower …

In November 1955, Geoffrey Harris published a paper based on the Christian A Herter
Lecture he had given earlier that year at Johns Hopkins University in Baltimore, MD, USA …

Energy expenditure and energy intake need to be balanced to maintain proper energy
homeostasis. Energy homeostasis is tightly regulated by the central nervous system, and the …