The transforming growth factor-β (TGF-β) signaling plays a critical role in the development
and tissue homeostasis in metazoans, and deregulation of TGF-β signaling leads to many …

Introduction Smad‐3, a key cytoplasmic mediator of transforming growth factor‐β (TGF‐β)
signalling, mediates many of its inflammatory and fibrotic effects in vivo (Roberts et al. 2001) …

Age-related diseases are associated with increased morbidity in the past few decades and
the cost associated with the treatment of these age-related diseases exerts a substantial …

Non-alcoholic fatty liver disease is one of the most common chronic liver diseases, ranging
from simple steatosis to steatohepatitis, fibrosis, and cirrhosis. Its prevalence is rapidly …

Based on development of various methodologies for isolation and characterization of
glycosphingolipids (GSLs), we have identified a number of GSLs with globo-series or lacto …

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, and its
advanced form non-alcoholic steatohepatitis (NASH) may progress to cirrhosis and …

301 Wnt/β-catenin pathway upregulation induced by TGF-β in DMEM with 20% foetal bovine
serum (FBS)(GibcoBRL, Grand Island, NY, USA)(5). Cells were grown in Dulbecco's …

Abstract Sphingosine‐1‐phosphate (S1P) is a bioactive lysosphingophospholipid that has
been implicated in the regulation of vital biological processes. Abundant evidence indicates …

Exposure of renal mesangial cells to sphingosine 1-phosphate (S1P) leads to a rapid and
transient activation of the mitogen-and stress-activated protein kinases but also the protein …

Transforming growth factor β (TGF-β) contributes to the progression of pulmonary fibrosis
through up-regulation of α–smooth muscle actin (α–SMA) as lung myofibroblast …