Chronic Obstructive Pulmonary disease (COPD) is an inflammatory syndrome that
represents an increasing health problem, especially in the elderly population. Drug …

The imbalance of epigenetic, oxidative stress and inflammatory markers is associated with
the aging physiopathology. Then, the influence of bioactive nutritional compounds and …

Exercise training (ET) is a natural activator of silent mating type information regulation 2
homolog 1 (SIRT1), a stress-sensor able to increase the endogenous antioxidant system …

Mammalian sirtuins (SIRT1-7) are NAD+-dependent deacetylases, which play an important
role in aging and in a wide range of cellular functions. SIRT1, the best-characterized …

Microvascular dysfunction often precedes other age-related macrovascular conditions and
predicts future cardiovascular risk. Sirtuin 1 (Sirt1) has recently emerged as a protein that …

Background. Cardiovascular diseases remain as the leading cause of morbidity and
mortality in industrialized countries. Ageing and gender strongly modulate the risk to …

Purpose Pulse wave velocity (PWV), an indicator of vascular stiffness, increases with age
and is increasingly recognized as an independent risk factor for cardiovascular disease …

The sirtuins comprise a highly conserved family proteins present in virtually all species from
bacteria to mammals. Sirtuins are members of the highly conserved class III histone …

Background: 8‐Hydroxy‐2′‐deoxyguanosine (8‐OHdG) and human neutrophil elastase/α1‐
proteinase inhibitor (HNE/α1‐PI) complex have been regarded as reliable biomarkers of …

Heart Failure (HF) is a syndrome, which implies the existence of different phenotypes. The
new categorization includes patients with preserved ejection fraction (HFpEF), mid-range EF …