The respiratory tract harbors a stable and diverse microbial population within an
extracellular mucus layer. Mucus provides a formidable defense against infection and …

Protein glycosylation is a widespread posttranslational modification that can impact the
function of proteins. Dysregulated protein glycosylation has been linked to several diseases …

Staphylococcus aureus is a predominant cause of chronic lung infections. While the airway
environment is rich in highly sialylated mucins, the interaction of S. aureus with sialic acid is …

Abstract Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) is a chloride and
bicarbonate channel in secretory epithelia with a critical role in maintaining fluid …

The dense O-glycosylation of mucins plays an important role in the defensive properties of
the mucus hydrogel. Aberrant glycosylation is often correlated with inflammation and …

The birth and adult development of “Dolly” the sheep, the first mammal produced by transfer
of a terminally differentiated cell nucleus into an egg, provided unequivocal evidence of …

Excessive lung inflammation and airway epithelial damage are hallmarks of human
inflammatory lung diseases, such as cystic fibrosis (CF). Enhancement of innate immunity …

Mucus stasis is a pathologic hallmark of muco-obstructive diseases, including cystic fibrosis
(CF). Mucins, the principal component of mucus, are extensively modified with hydroxyl (O) …

Complex respiratory diseases are a significant challenge for the livestock industry
worldwide. These diseases considerably impact animal health and welfare and cause …

Sialylation, a crucial post-translational modification of glycoconjugates, entails the
attachment of sialic acid (SA) to the terminal glycans of glycoproteins and glycolipids …