Acute inflammation or resolved inflammation is an adaptive host defense mechanism and is
self-limiting, which returns the body to a state of homeostasis. However, unresolved …

Simple Summary Some regions of aggressive malignancies experience hypoxia due to
inadequate blood supply. Cancer cells adapting to hypoxic conditions somehow become …

Introduction Ischemia–reperfusion injury (IRI) is the inexplicable aggravation of cellular
dysfunction that results in blood flow restoration to previously ischemic tissues. COX …

Currently, cancer treatment mainly consists of surgery, radiotherapy, chemotherapy,
immunotherapy, and molecular targeted therapy, of which radiotherapy is one of the major …

Cyclooxygenase (COX) enzymes are pivotal in inflammation and cancer development. COX-
2, in particular, has been implicated in tumor growth, angiogenesis, and immune evasion …

Triple‐negative breast cancer (TNBC) is a leading cause of cancer mortality and lacks
modern therapy options. Modulated electro‐hyperthermia (mEHT) is an adjuvant therapy …

The invention of immunotherapy, such as immune checkpoint inhibitors (ICIs) for advanced-
stage non-small cell lung cancer (NSCLC), has become a new standard of care for a defined …

Drug repurposing is a strategy used to develop new treatments based on approved or
investigational drugs outside the scope of their original clinical indication. Since this …

Simple Summary We present eight core attributes of cancer growth that we must address for
a more effective treatment than we currently have. To do this we outline why a regimen …

Background: Clinical studies have shown that celecoxib can significantly inhibit the
development of tumors, and basic experiments and in vitro experiments also provide a …