Occupancy and mechanism in antibody-mediated neutralization of animal viruses
PJ Klasse, QJ Sattentau - Journal of General Virology, 2002 - microbiologyresearch.org
Neutralization of virus infectivity by antibodies is an important component of immunity to
several virus infections. Here, the immunochemical basis for the action of neutralizing …
several virus infections. Here, the immunochemical basis for the action of neutralizing …
[HTML][HTML] CC chemokine receptor type five (CCR5): An emerging target for the control of HIV infection
F Barmania, MS Pepper - Applied & translational genomics, 2013 - Elsevier
When HIV was initially discovered as the causative agent of AIDS, many expected to find a
vaccine within a few years. This has however proven to be elusive; it has been …
vaccine within a few years. This has however proven to be elusive; it has been …
The BLT Humanized Mouse Model as a Tool for Studying Human Gamma Delta T Cell-HIV Interactions In Vivo
Gamma-delta (γδ) T cells recognize antigens in a major histocompatibility complex (MHC)
independent and have cytotoxic capability. Human immunodeficiency virus (HIV) infection …
independent and have cytotoxic capability. Human immunodeficiency virus (HIV) infection …
Effects of CCR5 and CD4 cell surface concentrations on infections by macrophagetropic isolates of human immunodeficiency virus type 1
EJ Platt, K Wehrly, SE Kuhmann, B Chesebro… - Journal of …, 1998 - Am Soc Microbiol
It has been proposed that changes in cell surface concentrations of coreceptors may control
infections by human immunodeficiency virus type 1 (HIV-1), but the mechanisms of …
infections by human immunodeficiency virus type 1 (HIV-1), but the mechanisms of …
Quantification of CD4, CCR5, and CXCR4 levels on lymphocyte subsets, dendritic cells, and differentially conditioned monocyte-derived macrophages
B Lee, M Sharron, LJ Montaner… - Proceedings of the …, 1999 - National Acad Sciences
CCR5 and CXCR4 are the major HIV-1 coreceptors for R5 and X4 HIV-1 strains,
respectively, and a threshold number of CD4 and chemokine receptor molecules is required …
respectively, and a threshold number of CD4 and chemokine receptor molecules is required …
Relative resistance to HIV–1 infection of CD4 lymphocytes from persons who remain uninfected despite multiple high–risk sexual exposures
WA Paxton, SR Martin, D Tse, TR O'Brien, J Skurnick… - Nature medicine, 1996 - nature.com
Some individuals remain uninfected with human immunodeficiency virus type–1 (HIV–1)
despite multiple high–risk sexual exposures. We studied a cohort of 25 subjects with …
despite multiple high–risk sexual exposures. We studied a cohort of 25 subjects with …
Structures of HIV-1 gp120 envelope glycoproteins from laboratory-adapted and primary isolates
PD Kwong, R Wyatt, S Majeed, J Robinson, RW Sweet… - Structure, 2000 - cell.com
Background: The gp120 exterior envelope glycoprotein of HIV-1 binds sequentially to CD4
and chemokine receptors on cells to initiate virus entry. During natural infection, gp120 is a …
and chemokine receptors on cells to initiate virus entry. During natural infection, gp120 is a …
Evidence that ecotropic murine leukemia virus contamination in TZM-bl cells does not affect the outcome of neutralizing antibody assays with human …
EJ Platt, M Bilska, SL Kozak, D Kabat… - Journal of …, 2009 - Am Soc Microbiol
The TZM-bl cell line that is commonly used to assess neutralizing antibodies against human
immunodeficiency virus type 1 (HIV-1) was recently reported to be contaminated with an …
immunodeficiency virus type 1 (HIV-1) was recently reported to be contaminated with an …
Antibody potency relates to the ability to recognize the closed, pre-fusion form of HIV Env
HIV's envelope glycoprotein (Env) is the sole target for neutralizing antibodies. The
structures of many broadly neutralizing antibodies (bNAbs) in complex with truncated Env …
structures of many broadly neutralizing antibodies (bNAbs) in complex with truncated Env …
Human immunodeficiency virus type 1 attachment to HeLa CD4 cells is CD4 independent and gp120 dependent and requires cell surface heparans
I Mondor, S Ugolini, QJ Sattentau - Journal of virology, 1998 - Am Soc Microbiol
The binding of human immunodeficiency virus type 1 (HIV-1)(Hx10) virions to two different
cell lines was analyzed by using a novel assay based on the detection, by anti-HLA-DR …
cell lines was analyzed by using a novel assay based on the detection, by anti-HLA-DR …