Amyotrophic lateral sclerosis (ALS) is a fatal disease, characterized by the degeneration of
both upper and lower motor neurons. Despite decades of research, we still to date lack a …

Sensory primary afferent fibers, conveying touch, pain, itch, and proprioception, synapse
onto spinal cord dorsal horn neurons. Primary afferent central terminals express a wide …

Descending pain inhibition is a key component of physiological and pathological pain
processing. 70 Various neurotransmitter systems underlie different descending pain …

Simple Summary Fiber pathways that descend from the brain to the spinal cord drive motor
behavior and modulate incoming sensory signals and the capacity to change (plasticity). A …

Persistent ocular pain caused by corneal inflammation and/or nerve injury is accompanied
by significant alterations along the pain axis. Both primary sensory neurons in the trigeminal …

Spinally projecting serotonergic neurons play a key role in controlling pain sensitivity and
can either increase or decrease nociception depending on physiological context. It is …

Pruritoceptive (dermal) itch was long considered an accompanying symptom of diseases, a
side effect of drug applications, or a temporary sensation induced by invading pruritogens …

The nociceptive network, responsible for transmission of nociceptive signals that generate
the pain experience, is not fully developed at birth. Descending serotonergic modulation of …

The supraspinal brain regions controlling defecation reflex remain to be elucidated. The
purpose of this study was to determine the roles of the hypothalamic A11 region and the …

The rostral ventromedial medulla (RVM) is a bulbospinal nuclei in the descending pain
modulation system, and directly affects spinal nociceptive transmission through …