[HTML][HTML] Current research trends of nanomedicines
Owing to the inherent shortcomings of traditional therapeutic drugs in terms of inadequate
therapeutic efficacy and toxicity in clinical treatment, nanomedicine designs have received …
therapeutic efficacy and toxicity in clinical treatment, nanomedicine designs have received …
Applications of nanotechnologies for miRNA-based cancer therapeutics: current advances and future perspectives
LA Bravo-Vázquez, A Méndez-García… - … in Bioengineering and …, 2023 - frontiersin.org
MicroRNAs (miRNAs) are short (18–25 nt), non-coding, widely conserved RNA molecules
responsible for regulating gene expression via sequence-specific post-transcriptional …
responsible for regulating gene expression via sequence-specific post-transcriptional …
[HTML][HTML] HMGA2 regulation by miRNAs in cancer: affecting cancer hallmarks and therapy response
M Hashemi, M Rashidi, K Hushmandi… - Pharmacological …, 2023 - Elsevier
High mobility group A 2 (HMGA2) is a protein that modulates the structure of chromatin in the
nucleus. Importantly, aberrant expression of HMGA2 occurs during carcinogenesis, and this …
nucleus. Importantly, aberrant expression of HMGA2 occurs during carcinogenesis, and this …
Oxidative stress and microRNAs in endothelial cells under metabolic disorders
Reactive oxygen species (ROS) are radical oxygen intermediates that serve as important
second messengers in signal transduction. However, when the accumulation of these …
second messengers in signal transduction. However, when the accumulation of these …
MicroRNA-mediated epigenetic regulation of inflammasomes in inflammatory responses and immunopathologies
YS Yi - Seminars in Cell & Developmental Biology, 2024 - Elsevier
Inflammation represents the first-line defense mechanism of the host against pathogens and
cellular stress. One of the most critical inflammatory responses is characterized by the …
cellular stress. One of the most critical inflammatory responses is characterized by the …
miRNA-based technologies in cancer therapy
The discovery of therapeutic miRNAs is one of the most exciting challenges for
pharmaceutical companies. Since the first miRNA was discovered in 1993, our knowledge of …
pharmaceutical companies. Since the first miRNA was discovered in 1993, our knowledge of …
MicroRNAs as novel biomarkers and potential therapeutic options for inflammatory cardiomyopathy
G Aleshcheva, C Baumeier, D Harms… - ESC Heart …, 2023 - Wiley Online Library
Aims Inflammation of the heart is a complex biological and pathophysiological response of
the immune system to a variety of injuries leading to tissue damage and heart failure …
the immune system to a variety of injuries leading to tissue damage and heart failure …
The Link between Diabetes, Pancreatic Tumors, and miRNAs—New Players for Diagnosis and Therapy?
M Kozłowska, A Śliwińska - International Journal of Molecular Sciences, 2023 - mdpi.com
Despite significant progress in medicine, pancreatic cancer is one of the most tardily
diagnosed cancer and is consequently associated with a poor prognosis and a low survival …
diagnosed cancer and is consequently associated with a poor prognosis and a low survival …
Differential Expression of MicroRNA MiR-145 and MiR-155 Downstream Targets in Oral Cancers Exhibiting Limited Chemotherapy Resistance
C Belnap, T Divis, K Kingsley, KM Howard - International Journal of …, 2024 - mdpi.com
New evidence has suggested that non-coding microRNAs play a significant role in
mediating and modulating chemotherapy resistance, particularly among oral cancers. One …
mediating and modulating chemotherapy resistance, particularly among oral cancers. One …
Chemotherapeutic drug resistance associated with differential miRNA expression of miR-375 and miR-27 among oral cancer cell lines
KC Huni, J Cheung, M Sullivan, WT Robison… - International Journal of …, 2023 - mdpi.com
Recent advances have suggested that non-coding miRNAs (such as miR-21, miR-27, miR-
145, miR-155, miR-365, miR-375 and miR-494) may be involved in multiple aspects of oral …
145, miR-155, miR-365, miR-375 and miR-494) may be involved in multiple aspects of oral …