Recent trends in biocatalysis
Biocatalysis has undergone revolutionary progress in the past century. Benefited by the
integration of multidisciplinary technologies, natural enzymatic reactions are constantly …
integration of multidisciplinary technologies, natural enzymatic reactions are constantly …
Biosynthesis and synthetic biology of psychoactive natural products
Psychoactive natural products play an integral role in the modern world. The tremendous
structural complexity displayed by such molecules confers diverse biological activities of …
structural complexity displayed by such molecules confers diverse biological activities of …
Merging enzymatic and synthetic chemistry with computational synthesis planning
Synthesis planning programs trained on chemical reaction data can design efficient routes
to new molecules of interest, but are limited in their ability to leverage rare chemical …
to new molecules of interest, but are limited in their ability to leverage rare chemical …
Synthetic anaplerotic modules for the direct synthesis of complex molecules from CO2
Anaplerosis is an essential feature of metabolism that allows the continuous operation of
natural metabolic networks, such as the citric acid cycle, by constantly replenishing drained …
natural metabolic networks, such as the citric acid cycle, by constantly replenishing drained …
Development of an efficient yeast platform for cannabigerolic acid biosynthesis
Cannabinoids are important therapeutical molecules for human ailments, cancer treatment,
and SARS-CoV-2. The central cannabinoid, cannabigerolic acid (CBGA), is generated from …
and SARS-CoV-2. The central cannabinoid, cannabigerolic acid (CBGA), is generated from …
A synthetic cell-free 36-enzyme reaction system for vitamin B12 production
Q Kang, H Fang, M Xiang, K Xiao, P Jiang… - Nature …, 2023 - nature.com
Adenosylcobalamin (AdoCbl), a biologically active form of vitamin B12 (coenzyme B12), is
one of the most complex metal-containing natural compounds and an essential vitamin for …
one of the most complex metal-containing natural compounds and an essential vitamin for …
Cannabis sativa: origin and history, glandular trichome development, and cannabinoid biosynthesis
Z Xie, Y Mi, L Kong, M Gao, S Chen… - Horticulture …, 2023 - academic.oup.com
Is Cannabis a boon or bane? Cannabis sativa has long been a versatile crop for fiber
extraction (industrial hemp), traditional Chinese medicine (hemp seeds), and recreational …
extraction (industrial hemp), traditional Chinese medicine (hemp seeds), and recreational …
Recent advances in biocatalysis for drug synthesis
A Kinner, P Nerke, R Siedentop, T Steinmetz… - Biomedicines, 2022 - mdpi.com
Biocatalysis is constantly providing novel options for the synthesis of active pharmaceutical
ingredients (APIs). In addition to drug development and manufacturing, biocatalysis also …
ingredients (APIs). In addition to drug development and manufacturing, biocatalysis also …
Screening microbially produced Δ9-tetrahydrocannabinol using a yeast biosensor workflow
Microbial production of cannabinoids promises to provide a consistent, cheaper, and more
sustainable supply of these important therapeutic molecules. However, scaling production to …
sustainable supply of these important therapeutic molecules. However, scaling production to …
Development of isopentenyl phosphate kinases and their application in terpenoid biosynthesis
As the largest class of natural products, terpenoids (> 90,000) have multiple biological
activities and a wide range of applications (eg, pharmaceutical, agricultural, personal care …
activities and a wide range of applications (eg, pharmaceutical, agricultural, personal care …