Background The efficacy of ceritinib in patients with untreated anaplastic lymphoma kinase
(ALK)-rearranged non-small-cell lung cancer (NSCLC) is not known. We assessed the …

Cisplatin and its platinum analogs, carboplatin and oxaliplatin, are some of the most widely
used cancer chemotherapeutics. Although cisplatin and carboplatin are used primarily in …

Purpose Cisplatin plus gemcitabine is a standard regimen for first-line treatment of
advanced non–small-cell lung cancer (NSCLC). Phase II studies of pemetrexed plus …

Purpose To compare single-agent pemetrexed (P) versus the combination of carboplatin
and pemetrexed (CP) in first-line therapy for patients with advanced non–small-cell lung …

Purpose To compare pemetrexed/carboplatin with a standard regimen as first-line therapy in
advanced non–small-cell lung cancer NSCLC. Patients and Methods Patients with stage IIIB …

Curcumin is a multifunctional phytochemical that has documented anti-oxidant, anti-
inflammatory and anti-tumor properties. The anti-tumor effect of curcumin has been widely …

Pemetrexed, a new cytotoxic agent, is a potent inhibitor of thymidylate synthetase and other
folate-dependent enzymes. Firstly, pemetrexed was approved in combination with cisplatin …

Introduction PRONOUNCE compared the efficacy and safety of pemetrexed+ carboplatin
followed by pemetrexed (Pem+ Cb) with paclitaxel+ carboplatin+ bevacizumab followed by …

背景与目的由于不同个体间肿瘤细胞的生物学特性差异以及现有药物在疗效和不良反应方面仍
存在的一定缺陷, 故本研究旨在比较培美曲塞及吉西他滨分别联合顺铂治疗初治晚期非小细胞 …

Objectives Platinum-based chemotherapy for advanced non–small-cell lung cancer
(NSCLC) has modest benefit overall, but has the potential to amplify immune responses. In …