Vaccine adjuvants: mechanisms and platforms

T Zhao, Y Cai, Y Jiang, X He, Y Wei, Y Yu… - Signal transduction and …, 2023 - nature.com
Adjuvants are indispensable components of vaccines. Despite being widely used in
vaccines, their action mechanisms are not yet clear. With a greater understanding of the …

Chemical and biomolecular strategies for STING pathway activation in cancer immunotherapy

KM Garland, TL Sheehy, JT Wilson - Chemical reviews, 2022 - ACS Publications
The stimulator of interferon genes (STING) cellular signaling pathway is a promising target
for cancer immunotherapy. Activation of the intracellular STING protein triggers the …

Adjuvants for coronavirus vaccines

Z Liang, H Zhu, X Wang, B Jing, Z Li, X Xia… - Frontiers in …, 2020 - frontiersin.org
Vaccine development utilizing various platforms is one of the strategies that has been
proposed to address the coronavirus disease 2019 (COVID-19) pandemic. Adjuvants are …

Nanoparticle-based strategies to combat COVID-19

R Medhi, P Srinoi, N Ngo, HV Tran… - ACS Applied Nano …, 2020 - ACS Publications
Coronavirus disease 2019 (COVID-19) is the worst pandemic disease of the current
millennium. This disease is caused by the highly contagious severe acute respiratory …

[HTML][HTML] Delivery of STING agonists for adjuvanting subunit vaccines

S Van Herck, B Feng, L Tang - Advanced drug delivery reviews, 2021 - Elsevier
Adjuvant is an essential component in subunit vaccines. Many agonists of pathogen
recognition receptors have been developed as potent adjuvants to optimize the …

Structure‐based varieties of polymeric nanocarriers and influences of their physicochemical properties on drug delivery profiles

R De, MK Mahata, KT Kim - Advanced Science, 2022 - Wiley Online Library
Carriers are equally important as drugs. They can substantially improve bioavailability of
cargos and safeguard healthy cells from toxic effects of certain therapeutics. Recently …

Manganese coordination micelles that activate stimulator of interferon genes and capture in situ tumor antigens for cancer metalloimmunotherapy

J Li, H Ren, Q Qiu, X Yang, J Zhang, C Zhang, B Sun… - ACS …, 2022 - ACS Publications
Cancer immunotherapy holds great promise but is generally limited by insufficient induction
of anticancer immune responses. Here, a metal micellar nanovaccine is developed by the …

Application prospect of polysaccharides in the development of anti-novel coronavirus drugs and vaccines

X Chen, W Han, G Wang, X Zhao - International journal of biological …, 2020 - Elsevier
Since the outbreak of the novel coronavirus disease COVID-19, caused by the SARS-CoV-2
virus, it has spread rapidly worldwide and poses a great threat to public health. This is the …

Nanoparticle-based drug delivery system: the magic bullet for the treatment of chronic pulmonary diseases

S Pramanik, S Mohanto, R Manne… - Molecular …, 2021 - ACS Publications
Chronic pulmonary diseases encompass different persistent and lethal diseases, including
chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), cystic …

Polymeric nanoparticle vaccines to combat emerging and pandemic threats

D Wibowo, SHT Jorritsma, ZJ Gonzaga, B Evert… - Biomaterials, 2021 - Elsevier
Subunit vaccines are more advantageous than live attenuated vaccines in terms of safety
and scale-up manufacture. However, this often comes as a trade-off to their efficacy. Over …