Metabolism and HSC fate: what NADPH is made for
C Morganti, M Bonora, K Ito - Trends in Cell Biology, 2024 - cell.com
Mitochondrial metabolism plays a central role in the regulation of hematopoietic stem cell
(HSC) biology. Mitochondrial fatty acid oxidation (FAO) is pivotal in controlling HSC self …
(HSC) biology. Mitochondrial fatty acid oxidation (FAO) is pivotal in controlling HSC self …
[HTML][HTML] The curious case of IDH mutant acute myeloid leukaemia: biochemistry and therapeutic approaches
E Gruber, LM Kats - Biochemical Society Transactions, 2023 - portlandpress.com
Of the many genetic alterations that occur in cancer, relatively few have proven to be
suitable for the development of targeted therapies. Mutations in isocitrate dehydrogenase …
suitable for the development of targeted therapies. Mutations in isocitrate dehydrogenase …
Non-inflamed tumor microenvironment and methylation/downregulation of antigen-presenting machineries in cholangiocarcinoma
N Nishida, T Aoki, M Morita, H Chishina, M Takita… - Cancers, 2023 - mdpi.com
Simple Summary Cholangiocarcinoma (CCA) is a chemotherapy-resistant cancer.
Reportedly, combination chemotherapy that includes immune checkpoint inhibitors (ICIs) …
Reportedly, combination chemotherapy that includes immune checkpoint inhibitors (ICIs) …
The human Stat1 gain-of-function T385M mutation causes expansion of activated T-follicular helper/T-helper 1-like CD4 T cells and sex-biased autoimmunity in …
O Scott, S Visuvanathan, E Reddy… - Frontiers in …, 2023 - frontiersin.org
Introduction Humans with gain-of-function (GOF) mutations in STAT1 (Signal Transducer
and Activator of Transcription 1), a potent immune regulator, experience frequent infections …
and Activator of Transcription 1), a potent immune regulator, experience frequent infections …
[HTML][HTML] PARP inhibitor plus radiotherapy reshape the immune suppressive microenvironment and potentiate the efficacy of immune checkpoint inhibitors in tumors …
X Hu, M Zhao, M Bai, Z Xue, F Wang, Z Zhu, J Yu… - Cancer Letters, 2024 - Elsevier
Isocitrate dehydrogenase 1 mutant (IDH1 mut) tumors respond poorly to immunotherapy, but
are more sensitive to chemoradiotherapy and poly (ADP-ribose) polymerase inhibition …
are more sensitive to chemoradiotherapy and poly (ADP-ribose) polymerase inhibition …
[PDF][PDF] Approaches to Study Tumor Metabolism in Mice
Y Gultekin, MG Vander Heiden… - Cold Spring Harbor …, 2023 - researchgate.net
Altered metabolism is a hallmark of cancer that reflects the increased energetic and
biosynthetic demands of proliferating cancer cells. Accumulating evidence suggests that …
biosynthetic demands of proliferating cancer cells. Accumulating evidence suggests that …
[PDF][PDF] Genetic/Epigenetic Alteration and Tumor Immune Microenvironment in Intrahepatic Cholangiocarcinoma: Transforming the Immune Microenvironment with …
N Nishida, M Kudo - Liver Cancer, 2024 - karger.com
Background: Intrahepatic cholangiocarcinoma (iCCA) is often diagnosed at an advanced
stage, leading to limited treatment options and a poor prognosis. So far, standard systemic …
stage, leading to limited treatment options and a poor prognosis. So far, standard systemic …
Correlation between the RNA Expression and the DNA Methylation of Estrogen Receptor Genes in Normal and Malignant Human Tissues
J Rong, X Xie, Y Niu, Z Su - Current Issues in Molecular Biology, 2024 - mdpi.com
Estrogen plays a multifaceted function in humans via interacting with the estrogen receptors
ERα, ERβ, and G protein-coupled estrogen receptor 1 (GPER1). Previous research has …
ERα, ERβ, and G protein-coupled estrogen receptor 1 (GPER1). Previous research has …