Potential role of microRNAs in the treatment and diagnosis of cervical cancer

S Shen, S Zhang, P Liu, J Wang, H Du - Cancer genetics, 2020 - Elsevier
Invasive cervical cancer is a leading cause of cancer death in women worldwide. miRNA
may have roles in the pathogenesis of cervical cancer based on the increases or decreases …

Epigenetic impact of infection on carcinogenesis: mechanisms and applications

N Hattori, T Ushijima - Genome medicine, 2016 - Springer
Viral and bacterial infections are involved in the development of human cancers, such as
liver, nasopharyngeal, cervical, head and neck, and gastric cancers. Aberrant DNA …

Safety, efficacy, and immunogenicity of VGX-3100, a therapeutic synthetic DNA vaccine targeting human papillomavirus 16 and 18 E6 and E7 proteins for cervical …

CL Trimble, MP Morrow, KA Kraynyak, X Shen… - The Lancet, 2015 - thelancet.com
Background Despite preventive vaccines for oncogenic human papillomaviruses (HPVs),
cervical intraepithelial neoplasia (CIN) is common, and current treatments are ablative and …

[HTML][HTML] Immune signature-based subtypes of cervical squamous cell carcinoma tightly associated with human papillomavirus type 16 expression, molecular features …

X Lu, L Jiang, L Zhang, Y Zhu, W Hu, J Wang, X Ruan… - Neoplasia, 2019 - Elsevier
Substantial heterogeneity exists within cervical cancer that is generally infected by human
papillomavirus (HPV). However, the most common histological subtype of cervical cancer …

Subtypes of HPV-positive head and neck cancers are associated with HPV characteristics, copy number alterations, PIK3CA mutation, and pathway signatures

Y Zhang, LA Koneva, S Virani, AE Arthur, A Virani… - Clinical Cancer …, 2016 - AACR
Purpose: There is substantial heterogeneity within human papillomavirus (HPV)-associated
head and neck cancer (HNC) tumors that predispose them to different outcomes; however …

Modulation of DNA methylation by human papillomavirus E6 and E7 oncoproteins in cervical cancer

P Sen, P Ganguly, N Ganguly - Oncology letters, 2018 - spandidos-publications.com
Human papillomaviruses (HPVs) are double stranded circular DNA viruses that infect
cutaneous and mucosal epithelial cells. Almost 99% of cervical cancer has a HPV infection …

Human papilloma virus, DNA methylation and microRNA expression in cervical cancer

H Jiménez-Wences, O Peralta-Zaragoza… - Oncology …, 2014 - spandidos-publications.com
Cancer is a complex disease caused by genetic and epigenetic abnormalities that affect
gene expression. The progression from precursor lesions to invasive cervical cancer is …

Molecular Pathways: Involvement of Helicobacter pylori–Triggered Inflammation in the Formation of an Epigenetic Field Defect, and Its Usefulness as Cancer Risk …

T Ushijima, N Hattori - Clinical Cancer Research, 2012 - AACR
Infection-associated cancers account for a large proportion of human cancers, and gastric
cancer, the vast majority of which is associated with Helicobacter pylori infection, is a typical …

Genome-wide DNA methylation assay reveals novel candidate biomarker genes in cervical cancer

SA Farkas, N Milutin-Gašperov, M Grce, TK Nilsson - Epigenetics, 2013 - Taylor & Francis
The oncogenic human papilloma viruses (HPVs) are associated with precancerous cervical
lesions and development of cervical cancer. The DNA methylation signatures of the host …

Transcriptional repression of E-cadherin by human papillomavirus type 16 E6

ZJ D'Costa, C Jolly, EJ Androphy, A Mercer… - PloS one, 2012 - journals.plos.org
There is increasing evidence supporting DNA virus regulation of the cell adhesion and
tumour suppressor protein, E-cadherin. We previously reported that loss of E-cadherin in …