Inflammation in schizophrenia: pathogenetic aspects and therapeutic considerations

N Müller - Schizophrenia bulletin, 2018 - academic.oup.com
This paper discusses the current evidence from animal and human studies for a central role
of inflammation in schizophrenia. In animal models, pre-or perinatal elicitation of the immune …

Alteration patterns of peripheral concentrations of cytokines and associated inflammatory proteins in acute and chronic stages of schizophrenia: a systematic review …

S Halstead, D Siskind, M Amft, E Wagner… - The Lancet …, 2023 - thelancet.com
Background Immune system dysfunction is considered to play an aetiological role in
schizophrenia spectrum disorders, with substantial alterations in the concentrations of …

Schizophrenia and inflammation research: a bibliometric analysis

HL Sun, W Bai, XH Li, H Huang, XL Cui… - Frontiers in …, 2022 - frontiersin.org
Background Schizophrenia (SCZ) is a severe psychiatric disorder that involves inflammatory
processes. The aim of this study was to explore the field of inflammation-related research in …

Antipsychotics: mechanisms underlying clinical response and side-effects and novel treatment approaches based on pathophysiology

SJ Kaar, S Natesan, R Mccutcheon, OD Howes - Neuropharmacology, 2020 - Elsevier
Antipsychotic drugs are central to the treatment of schizophrenia and other psychotic
disorders but are ineffective for some patients and associated with side-effects and …

Glutamate hypothesis in schizophrenia

Y Uno, JT Coyle - Psychiatry and clinical neurosciences, 2019 - Wiley Online Library
Schizophrenia is a chronic and severe psychiatric disorder that has profound impact on an
individual's life and on society. Thus, developing more effective therapeutic interventions is …

A meta-analysis of blood cytokine network alterations in psychiatric patients: comparisons between schizophrenia, bipolar disorder and depression

DR Goldsmith, MH Rapaport, BJ Miller - Molecular psychiatry, 2016 - nature.com
Schizophrenia, bipolar disorder and major depressive disorder (MDD) have all been
associated with aberrant blood cytokine levels; however, neither the pattern of cytokine …

The inflamed brain in schizophrenia: the convergence of genetic and environmental risk factors that lead to uncontrolled neuroinflammation

AL Comer, M Carrier, MÈ Tremblay… - Frontiers in cellular …, 2020 - frontiersin.org
Schizophrenia is a disorder with a heterogeneous etiology involving complex interplay
between genetic and environmental risk factors. The immune system is now known to play …

Cytokine alterations in schizophrenia: an updated review

S Momtazmanesh, A Zare-Shahabadi… - Frontiers in …, 2019 - frontiersin.org
Schizophrenia, a multisystem disorder with an unknown etiology, is associated with several
immune dysfunctions, including abnormal levels of circulating cytokines. In this review, we …

Significant locus and metabolic genetic correlations revealed in genome-wide association study of anorexia nervosa

L Duncan, Z Yilmaz, H Gaspar… - American journal of …, 2017 - Am Psychiatric Assoc
Objective: The authors conducted a genome-wide association study of anorexia nervosa
and calculated genetic correlations with a series of psychiatric, educational, and metabolic …

Neuroinflammation in schizophrenia: the role of nuclear factor kappa B

CE Murphy, AK Walker, CS Weickert - Translational psychiatry, 2021 - nature.com
Neuroinflammation, particularly in the dorsolateral prefrontal cortex, is well-established in a
subset of people with schizophrenia, with significant increases in inflammatory markers …