Thrombosis is the most feared complication of cardiovascular diseases and a main cause of
death worldwide, making it a major health-care challenge. Platelets and the coagulation …

During severe inflammatory and infectious diseases, various mediators modulate the
equilibrium of vascular tone, inflammation, coagulation and thrombosis. This Review …

The association between inflammation, infection, and venous thrombosis has long been
recognized; yet, only in the last decades have we begun to understand the mechanisms …

C-reactive protein (CRP) is a member of the highly conserved pentraxin superfamily of
proteins and is often used in clinical practice as a marker of infection and inflammation …

Deep vein thrombosis (DVT) is a major origin of morbidity and mortality. While DVT has long
been considered as blood coagulation disorder, several recent lines of evidence …

Innate immunity is fundamental to our defense against microorganisms. Physiologically, the
intravascular innate immune system acts as a purging system that identifies and removes …

Reactive oxygen species (ROS) have physiological roles as second messengers, but can
also exert detrimental modifications on DNA, proteins and lipids if resulting from enhanced …

A mutual relationship exists between immune activation and mechanisms of thrombus
formation. In particular, elements of the innate immune response such as the complement …

Abstract C1 inhibitor (C1INH) is a multifunctional serine protease inhibitor that functions as a
major negative regulator of several biological pathways, including the contact pathway of …

Appropriate activation of coagulation requires a balance between procoagulant and
anticoagulant proteins in blood. Loss in this balance leads to hemorrhage and thrombosis. A …