Prostate cancer genetic risk and associated aggressive disease in men of African ancestry

PXY Soh, N Mmekwa, DC Petersen, K Gheybi… - Nature …, 2023 - nature.com
African ancestry is a significant risk factor for prostate cancer and advanced disease. Yet,
genetic studies have largely been conducted outside the context of Sub-Saharan Africa …

Linking African ancestral substructure to prostate cancer health disparities

K Gheybi, N Mmekwa, MT Lebelo, SM Patrick… - Scientific Reports, 2023 - nature.com
Prostate cancer (PCa) is a significant health burden in Sub-Saharan Africa, with mortality
rates loosely linked to African ancestry. Yet studies aimed at identifying contributing risk …

Cancer genetic mutation prevalence in sub-Saharan Africa: A review of existing data

J Shain, A Michel, MS May, L Qunaj, W El-Sadr… - Seminars in …, 2023 - Elsevier
Background Cancer represents a leading cause of death worldwide. Germline mutations in
several genes increase the risk of developing several cancers, including cancers of the …

The impact of telomere length on prostate cancer aggressiveness, genomic instability and health disparities

R Huang, MSR Bornman, PD Stricker, I Simoni Brum… - Scientific Reports, 2024 - nature.com
The telomere repetitive TTAGGG motif at the ends of chromosomes, serves to preserve
genomic integrity and chromosomal stability. In turn, genomic instability is a hallmark of …

Common genetic variants associated with prostate cancer risk: the need for African inclusion

PXY Soh, VM Hayes - European urology, 2023 - pubmed.ncbi.nlm.nih.gov
Common Genetic Variants Associated with Prostate Cancer Risk: The Need for African Inclusion
Common Genetic Variants Associated with Prostate Cancer Risk: The Need for African Inclusion …

[HTML][HTML] Health equity research outcomes and improvement Consortium Prostate Cancer Health Precision Africa1K: closing the health equity gap through rural …

VM Hayes, SM Patrick, J Shirinde… - Journal of Urologic …, 2024 - e-juo.org
Prostate cancer shows significant racial disparity, with men of African ancestry
disproportionately impacted. While prostate cancer health disparity studies focus on …

Alterations in the epigenetic machinery associated with prostate cancer health disparities

J Craddock, J Jiang, SM Patrick, SBA Mutambirwa… - Cancers, 2023 - mdpi.com
Simple Summary African ancestry is a significant risk factor for aggressive prostate cancer
(PCa), with southern African ethnicity conferring a nearly 3-fold increased global risk for …

A Comparison of 68Ga-PSMA PET/CT-Based Split Renal Function with 99mTc-MAG3 Renography in Patients with Metastatic Castration-Resistant Prostate Carcinoma Treated …

L Gabela, T Mkhize, B Hadebe, L Harry, T Nxasana… - Diagnostics, 2024 - mdpi.com
Background: Physiological PSMA expression in the cells of the proximal renal tubules and
consecutive radiopharmaceutical binding and retention could potentially lead to radioligand …

Rare pathogenic structural variants show potential to enhance prostate cancer germline testing for African men

V Hayes, T Gong, J Jiang, R Bornman, K Gheybi… - 2024 - researchsquare.com
Prostate cancer (PCa) is highly heritable, with men of African ancestry at greatest risk and
associated lethality. Lack of representation in genomic data means germline testing …

The 20th Annual Prostate Cancer Foundation Scientific Retreat report

AK Miyahira, JW Simons, HR Soule - The Prostate, 2014 - Wiley Online Library
The 20th Annual Prostate Cancer Foundation (PCF) Scientific Retreat was held from
October 24 to 26, 2013, in National Harbor, Maryland. This event is held annually for the …