Maintenance of protein homeostasis and organelle integrity and function is critical for
cellular homeostasis and cell viability. Autophagy is the principal mechanism that mediates …

Chronic caloric restriction (CR) has powerful anticarcinogenic actions in both preclinical and
clinical studies but may be difficult to sustain. As an alternative to CR, there has been …

Autophagy is a critical cellular process that generally protects cells and organisms from
stressors such as nutrient deprivation. In addition to its role in normal physiology, autophagy …

Cancer recurrence after initial diagnosis and treatment is a major cause of breast cancer
(BC) mortality, which results from the metastatic outbreak of dormant tumour cells …

Obesity poses a severe threat to human health, including the increased prevalence of
hypertension, insulin resistance, diabetes mellitus, cancer, inflammation, sleep apnoea and …

Cancer is a daunting global problem confronting the world's population. The most frequent
therapeutic approaches include surgery, chemotherapy, radiotherapy, and more recently …

Tumor-associated inflammation is predictive of poor prognosis and drives a variety of
tumorigenic phenotypes, including tumor proliferation and survival, angiogenesis …

Macroautophagy/autophagy is a fundamental intracellular degradation process with multiple
roles in immunity, including direct elimination of intracellular microorganisms via …

Selective autophagy is a conserved homeostatic pathway that involves engulfment of
specific cargo molecules into specialized organelles called autophagosomes. The ubiquitin …

In recent decades, cancer stem cells (CSCs) have been increasingly identified in many
malignancies. CSC-related signaling pathways and their functions provide new strategies …