Anti-trypanosomatid drug discovery: progress and challenges

M De Rycker, S Wyllie, D Horn, KD Read… - Nature Reviews …, 2023 - nature.com
Leishmaniasis (visceral and cutaneous), Chagas disease and human African
trypanosomiasis cause substantial death and morbidity, particularly in low-and middle …

Human african trypanosomiasis

P Büscher, G Cecchi, V Jamonneau, G Priotto - The Lancet, 2017 - thelancet.com
Human African trypanosomiasis (sleeping sickness) is a parasitic infection that almost
invariably progresses to death unless treated. Human African trypanosomiasis caused …

Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need

MC Field, D Horn, AH Fairlamb… - Nature Reviews …, 2017 - nature.com
The WHO recognizes human African trypanosomiasis, Chagas disease and the
leishmaniases as neglected tropical diseases. These diseases are caused by parasitic …

Monitoring the elimination of human African trypanosomiasis: Update to 2014

JR Franco, G Cecchi, G Priotto, M Paone… - PLoS neglected …, 2017 - journals.plos.org
Background The World Health Organization (WHO) has targeted the elimination of Human
African trypanosomiasis (HAT)'as a public health problem'by 2020. The selected indicators …

Monitoring the elimination of human African trypanosomiasis at continental and country level: Update to 2018

JR Franco, G Cecchi, G Priotto, M Paone… - PLoS neglected …, 2020 - journals.plos.org
Background In 2012 human African trypanosomiasis (HAT), also known as sleeping
sickness, was targeted for elimination as a public health problem, set to be achieved by …

Clinical and neuropathogenetic aspects of human African trypanosomiasis

PGE Kennedy, J Rodgers - Frontiers in immunology, 2019 - frontiersin.org
Trypanosomiasis has been recognized as a scourge in sub-Saharan Africa for centuries.
The disease, caused by protozoan parasites of the Trypanosoma genus, is a major cause of …

Do cryptic reservoirs threaten gambiense-sleeping sickness elimination?

P Büscher, JM Bart, M Boelaert, B Bucheton… - Trends in …, 2018 - cell.com
Trypanosoma brucei gambiense causes human African trypanosomiasis (HAT). Between
1990 and 2015, almost 440000 cases were reported. Large-scale screening of populations …

Update on human African trypanosomiasis (sleeping sickness)

PGE Kennedy - Journal of neurology, 2019 - Springer
Human African trypanosomiasis (HAT), also known as sleeping sickness, is one of the
Africa's' neglected diseases' and is caused by infection with protozoan parasites of the …

Oligopeptide signaling through TbGPR89 drives trypanosome quorum sensing

F Rojas, E Silvester, J Young, R Milne, M Tettey… - Cell, 2019 - cell.com
Trypanosome parasites control their virulence and spread by using quorum sensing (QS) to
generate transmissible" stumpy forms" in their host bloodstream. However, the QS signal" …

Mitochondrion of the Trypanosoma brucei long slender bloodstream form is capable of ATP production by substrate-level phosphorylation

G Taleva, M Husová, B Panicucci, C Hierro-Yap… - PLoS …, 2023 - journals.plos.org
The long slender bloodstream form Trypanosoma brucei maintains its essential
mitochondrial membrane potential (ΔΨm) through the proton-pumping activity of the FoF1 …