Vitamin C (Ascorbic Acid), the antiscorbutic vitamin, cannot be synthesized by humans and
other primates, and has to be obtained from diet. Ascorbic acid is an electron donor and acts …

Thrombocytopenia is a common problem in cancer patients. Aside from bleeding risk,
thrombocytopenia limits chemotherapy dose and frequency. In evaluating thrombocytopenic …

Hypoxia inducible factors (HIFs) are α/β heterodimeric transcription factors that direct
multiple cellular and systemic responses in response to changes in oxygen availability. The …

The production of erythropoietin (EPO), the main regulator of erythroid differentiation, is
regulated by hypoxia-inducible factor (HIF). HIF2α seems to be the principal regulator of …

Long overlooked as the virtual compartment and then strictly characterized through
descriptive morphologic analysis, the renal interstitium has finally been associated with …

Cellular senescence is a complex physiological state whose main feature is proliferative
arrest. Cellular senescence can be considered the reverse of cell immortalization and …

Every cell in the body requires oxygen for its functioning, in virtually every animal, and a
tightly regulated system that balances oxygen supply and demand is therefore fundamental …

Hepcidin, the main regulator of iron homeostasis, is repressed when erythropoiesis is
acutely stimulated by erythropoietin (EPO) to favor iron supply to maturing erythroblasts …

Adequate acclimatization time to enable adjustment to hypoxic conditions is one of the most
important aspects for mountaineers ascending to high altitude. Accordingly, most reviews …

Erythropoiesis is a complex process driving the production of red blood cells. During
homeostasis, adult erythropoiesis takes place in the bone marrow and is tightly controlled by …