Microbial polyketides and their roles in insect virulence: from genomics to biological functions

W Toopaang, W Bunnak, C Srisuksam… - Natural Product …, 2022 - pubs.rsc.org
Covering: May 1966 up to January 2022 Entomopathogenic microorganisms have potential
for biological control of insect pests. Their main secondary metabolites include polyketides …

Facilitating drug discovery in human disease models using insects

Y Matsumoto - Biological and Pharmaceutical Bulletin, 2020 - jstage.jst.go.jp
Drugs are developed through basic studies and clinical trials. In basic studies, researchers
seek drug candidates using in vitro evaluation systems and subsequently examine their …

Products of Sericulture and Their Hypoglycemic Action Evaluated by Using the Silkworm, Bombyx mori (Lepidoptera: Bombycidae), as a Model

SD Aznar-Cervantes, B Monteagudo Santesteban… - Insects, 2021 - mdpi.com
Simple Summary The use of invertebrates as animal models is gaining attention within the
scientific community due to numerous advantages during the development of the …

Silkworm model of biofilm formation: In vivo evaluation of antimicrobial tolerance of a cross-kingdom dual-species (Escherichia coli and Candida albicans) biofilm …

S Eshima, Y Matsumoto, S Kurakado, T Sugita - PLoS One, 2023 - journals.plos.org
Biofilms are formed by microorganisms and their products on the surface of materials such
as medical devices. Biofilm formation protects microorganisms from antimicrobial agents …

Comparing the virulence of four major clades of Candida auris strains using a silkworm infection model: Clade IV isolates had higher virulence than the other clades

S Kurakado, Y Matsumoto, T Sugita - Medical Mycology, 2023 - academic.oup.com
Candida auris is an emerging fungal pathogen that is feared to spread of infection because
of its propensity for multidrug resistance and high mortality rate. This pathogenic yeast is …

Genetic differences between Japan and other countries in cyp51A polymorphisms of Aspergillus fumigatus

H Majima, T Arai, Y Kusuya, H Takahashi… - Mycoses, 2021 - Wiley Online Library
Background Mutations in cyp51A gene are known as main mechanisms of azole resistance
in Aspergillus fumigatus, whereas azole‐susceptible strains also carry cyp51A mutations …

Caenorhabditis elegans as an Infection Model for Pathogenic Mold and Dimorphic Fungi: Applications and Challenges

CS Ahamefule, BC Ezeuduji, JC Ogbonna… - Frontiers in Cellular …, 2021 - frontiersin.org
The threat burden from pathogenic fungi is universal and increasing with alarming high
mortality and morbidity rates from invasive fungal infections. Understanding the virulence …

The Response of the Estrogen-Related Receptor to 20-Hydroxyecdysone in Bombyx mori: Insight Into the Function of Estrogen-Related Receptor in Insect 20 …

J Wu, G Shen, D Liu, H Xu, M Jiao, Y Zhang… - Frontiers in …, 2022 - frontiersin.org
Estrogen-related receptor (ERR) is an orphan nuclear receptor that was first discovered in
animals, and play an important role in metabolism, development, and reproduction. Despite …

In vivo efficacy of pitavastatin combined with itraconazole against Aspergillus fumigatus in silkworm models

H Majima, T Arai, K Kamei, A Watanabe - Microbiology Spectrum, 2023 - Am Soc Microbiol
Azole resistance in Aspergillus fumigatus is a worldwide concern and new antifungal drugs
are required to overcome this problem. Statin, a 3-hydroxy-3-methylglutaryl-coenzyme A …

A novel silkworm infection model with fluorescence imaging using transgenic Trichosporon asahii expressing eGFP

Y Matsumoto, H Yamazaki, Y Yamasaki, Y Tateyama… - Scientific Reports, 2020 - nature.com
Trichosporon asahii is a pathogenic fungus that causes deep mycosis in patients with
neutropenia. Establishing an experimental animal model for quantitatively evaluating …