Cyclin-dependent kinases in breast cancer: expression pattern and therapeutic implications
Presently, breast cancer (BC) is one of the most common malignancies diagnosed and the
leading cause of tumor-related deaths among women worldwide. Cell cycle dysregulation is …
leading cause of tumor-related deaths among women worldwide. Cell cycle dysregulation is …
Targeting CDK2 in cancer: challenges and opportunities for therapy
Highlights•CDK2 has key roles in cell cycle, DNA replication and DNA damage.•Multiple
biomarkers can indicate increased CDK2 activity.•Some cancers have particular …
biomarkers can indicate increased CDK2 activity.•Some cancers have particular …
Inhibitors of cyclin-dependent kinases as cancer therapeutics
SR Whittaker, A Mallinger, P Workman… - Pharmacology & …, 2017 - Elsevier
Over the past two decades there has been a great deal of interest in the development of
inhibitors of the cyclin-dependent kinases (CDKs). This attention initially stemmed from …
inhibitors of the cyclin-dependent kinases (CDKs). This attention initially stemmed from …
CDK7 inhibitors as anticancer drugs
GP Sava, H Fan, RC Coombes, L Buluwela… - Cancer and Metastasis …, 2020 - Springer
Abstract Cyclin-dependent kinase 7 (CDK7), along with cyclin H and MAT1, forms the CDK-
activating complex (CAK), which directs progression through the cell cycle via T-loop …
activating complex (CAK), which directs progression through the cell cycle via T-loop …
Targeting CDK9 reactivates epigenetically silenced genes in cancer
Summary Cyclin-dependent kinase 9 (CDK9) promotes transcriptional elongation through
RNAPII pause release. We now report that CDK9 is also essential for maintaining gene …
RNAPII pause release. We now report that CDK9 is also essential for maintaining gene …
CDK7 inhibitor THZ1 enhances antiPD-1 therapy efficacy via the p38α/MYC/PD-L1 signaling in non-small cell lung cancer
J Wang, R Zhang, Z Lin, S Zhang, Y Chen… - Journal of Hematology & …, 2020 - Springer
Background The cyclin-dependent kinase 7 (CDK7) subunit of TFIIH regulates RNA
polymerase-II-based transcription and promotes tumor progression. However, the …
polymerase-II-based transcription and promotes tumor progression. However, the …
ICEC0942, an orally bioavailable selective inhibitor of CDK7 for cancer treatment
H Patel, M Periyasamy, GP Sava, A Bondke… - Molecular cancer …, 2018 - AACR
Recent reports indicate that some cancer types are especially sensitive to transcription
inhibition, suggesting that targeting the transcriptional machinery provides new approaches …
inhibition, suggesting that targeting the transcriptional machinery provides new approaches …
The essential and multifunctional TFIIH complex
JK Rimel, DJ Taatjes - Protein Science, 2018 - Wiley Online Library
TFIIH is a 10‐subunit complex that regulates RNA polymerase II (pol II) transcription but also
serves other important biological roles. Although much remains unknown about TFIIH …
serves other important biological roles. Although much remains unknown about TFIIH …
[HTML][HTML] An insight into the emerging role of cyclin-dependent kinase inhibitors as potential therapeutic agents for the treatment of advanced cancers
Cancer denotes a pathological manifestation that is characterized by hyperproliferation of
cells. It has anticipated that a better understanding of disease pathogenesis and the role of …
cells. It has anticipated that a better understanding of disease pathogenesis and the role of …
Therapeutic targeting of transcriptional cyclin-dependent kinases
MD Galbraith, H Bender, JM Espinosa - Transcription, 2019 - Taylor & Francis
The fact that many cancer types display transcriptional addiction driven by dysregulation of
oncogenic enhancers and transcription factors has led to increased interest in a group of …
oncogenic enhancers and transcription factors has led to increased interest in a group of …