Abstract The Ser/Thr kinase mechanistic target of rapamycin (mTOR) is a central regulator of
cellular metabolism. As part of mTOR complex 1 (mTORC1), mTOR integrates signals such …

The mechanistic target of rapamycin complex 1 (mTORC1) signaling hub integrates multiple
environmental cues to modulate cell growth and metabolism. Over the past decade …

Evolutionary development of the human brain is characterized by the expansion of various
brain regions. Here, we show that developmental processes specific to humans are …

Altered synaptic structure and function is a major hallmark of fragile X syndrome (FXS),
autism spectrum disorders (ASDs), and other intellectual disabilities (IDs), which are …

The protein kinase complex mechanistic target of rapamycin complex 1 (mTORC1) serves
as a key conduit between growth signals and the metabolic processes underlying cell …

The mechanistic target of rapamycin signalling pathway serves as a ubiquitous regulator of
cell metabolism, growth, proliferation and survival. The main cellular activity of the …

Kidney cancer is not a single disease but represents several distinct types of cancer that
have defining histologies and genetic alterations and that follow different clinical courses …

The mammalian target of rapamycin, mTOR, plays key roles in cell growth and proliferation,
acting at the catalytic subunit of two protein kinase complexes: mTOR complexes 1 and 2 …

Cell division and organismal development are exquisitely orchestrated and regulated
processes. The dysregulation of the molecular mechanisms underlying these processes …

Systemic lupus erythematosus (SLE) is a chronic multi-organ debilitating autoimmune
disease, which mainly afflicts women in the reproductive years. A complex interaction of …