Propofol (2, 6‐diisopropylphenol) is a versatile, short‐acting, intravenous (iv) sedative‐
hypnotic agent initially marketed as an anesthetic, and now also widely used for the …

In all mammalian species, breathing is controlled by a neuronal network within the lower
brainstem. A component known as the ventral respiratory group produces rhythmic activity …

Antifibrinolytic drugs are widely used to reduce blood loss during surgery. One serious
adverse effect of these drugs is convulsive seizures; however, the mechanisms underlying …

Background and objective: Thymol is a naturally occurring phenol derivative used in
anaesthetic practice as a stabilizer and preservative of halothane, usually at a concentration …

General anesthetics depress excitatory and/or enhance inhibitory synaptic transmission
principally by modulating the function of glutamatergic or GABAergic synapses, respectively …

A series of 27 analogs of the general anesthetic propofol (2, 6-diisopropylphenol) were
examined for general anesthetic activity in Xenopus laevis tadpoles and for the ability to …

Background Propofol has not been studied directly in animals subject to cerebral ischemia
in the conscious state. Strokes are usually induced in animals while they are anesthetized …

Key points• Transcranial magnetic stimulation (TMS) is a popular technique for the non‐
invasive investigation of motor function and is often assumed to influence spinal circuits …

Mounting electrophysiological evidence indicates that certain general anesthetics, volatile
anesthetics in particular, depress excitatory synaptic transmission by presynaptic …

Background Controversy persists concerning the mechanisms and role of general
anesthetic inhibition of glutamate release from nerve endings. To determine the generality of …