Monoclonal antibodies for the treatment of cancer

CW Shuptrine, R Surana, LM Weiner - Seminars in cancer biology, 2012 - Elsevier
Over the past decade, the clinical utility of monoclonal antibodies has been realized and
antibodies are now a mainstay for the treatment of cancer. Antibodies have the unique …

Management of cutaneous squamous cell carcinoma in patients with epidermolysis bullosa: best clinical practice guidelines

JE Mellerio, SJ Robertson, C Bernardis… - British Journal of …, 2016 - academic.oup.com
This article summarizes recommendations reached following a systematic literature review
and expert consensus on the diagnosis and management of cutaneous squamous cell …

Biological determinants of radioresistance and their remediation in pancreatic cancer

P Seshacharyulu, MJ Baine, JJ Souchek… - … et Biophysica Acta (BBA …, 2017 - Elsevier
Despite recent advances in radiotherapy, a majority of patients diagnosed with pancreatic
cancer (PC) do not achieve objective responses due to the existence of intrinsic and …

[HTML][HTML] Nimotuzumab: beyond the EGFR signaling cascade inhibition

Z Mazorra, L Chao, A Lavastida, B Sanchez… - Seminars in …, 2018 - Elsevier
One of the most known oncogenes is the epidermal growth factor receptor (EGFR) family. It
activates multiple signaling cascades that promote carcinogenesis and immune evasion …

Approval summary: cetuximab in combination with cisplatin or carboplatin and 5‐fluorouracil for the first‐line treatment of patients with recurrent locoregional or …

MH Cohen, H Chen, S Shord, C Fuchs, K He… - The …, 2013 - academic.oup.com
Abstract Learning Objectives Compare survival outcomes among patients with SCCHN
treated with a platinum/5‐FU regimen with and without cetuximab. Compare adverse event …

mTHPC mediated photodynamic therapy (PDT) of squamous cell carcinoma in the head and neck: a systematic review

SAHJ de Visscher, PU Dijkstra, IB Tan… - Oral oncology, 2013 - Elsevier
OBJECTIVE: Photodynamic therapy (PDT) is used in curative and palliative treatment of
head and neck squamous cell carcinoma (HNSCC). To evaluate available evidence on the …

[HTML][HTML] Inhibition of radiation induced migration of human head and neck squamous cell carcinoma cells by blocking of EGF receptor pathways

AC Pickhard, J Margraf, A Knopf, T Stark, G Piontek… - BMC cancer, 2011 - Springer
Background Recently it has been shown that radiation induces migration of glioma cells and
facilitates a further spread of tumor cells locally and systemically. The aim of this study was …

[HTML][HTML] Immune biomarkers of anti-EGFR monoclonal antibody therapy

S Trivedi, F Concha-Benavente, RM Srivastava… - Annals of …, 2015 - Elsevier
The tumor antigen (TA)-targeted monoclonal antibodies (mAb) cetuximab and panitumumab
target the human epidermal growth factor receptor and have been integrated into treatment …

Toxicities of systemic agents in squamous cell carcinoma of the head and neck (SCCHN); A new perspective in the era of immunotherapy

NF Saba, MD Mody, ES Tan, HS Gill, A Rinaldo… - Critical Reviews in …, 2017 - Elsevier
Squamous cell carcinoma of the head and neck (SCCHN) is a difficult to treat malignancy
and represents the seventh most common cancer worldwide. Systemic therapy has a critical …

[HTML][HTML] Advances in molecular targeted therapies to increase efficacy of (chemo) radiation therapy

K Viktorsson, T Rieckmann, M Fleischmann… - Strahlentherapie und …, 2023 - Springer
Recent advances in understanding the tumor's biology in line with a constantly growing
number of innovative technologies have prompted characterization of patients' individual …