Huntington's disease (HD) is a fully penetrant neurodegenerative disease caused by a
dominantly inherited CAG trinucleotide repeat expansion in the huntingtin gene on …

Neurodegenerative diseases are a common cause of morbidity and cognitive impairment in
older adults. Most clinicians who care for the elderly are not trained to diagnose these …

Alzheimer's disease (AD) is the most common cause of dementia and is characterized by
progressive neurodegeneration and cognitive decline. Understanding the pathophysiology …

Purpose: This systematic review examines research and practical applications of the World
Health Organization Disability Assessment Schedule (WHODAS 2.0) as a basis for …

Among the age-dependent protein aggregation disorders, nine neurodegenerative diseases
are caused by expansions of CAG repeats encoding polyglutamine (polyQ) tracts. We …

Abstract The Research Domain Criteria (RDoC) paradigm was launched 10 years ago as a
superior approach for investigation of mental illness. RDoC conceptualizes normal human …

Significant progress has been made in understanding the pre-symptomatic phase of
amyotrophic lateral sclerosis. While much is still unknown, advances in other …

The longitudinal dynamics of the most promising biofluid biomarker candidates for
Huntington's disease (HD)—mutant huntingtin (mHTT) and neurofilament light (NfL)—are …

Background Huntington's disease is a rare, neurodegenerative disease caused by an
expanded CAG repeat mutation in the huntingtin gene. Compared with adult-onset …

Huntington's disease (HD) is traditionally considered as a triad of movement, cognitive, and
emotional disorders. 1–4 According to current clinical practice,“manifest HD” is diagnosed …