Telomerase reverse transcriptase (TERT) is a catalytic subunit of telomerase. Telomerase
complex plays a key role in cancer formation by telomere dependent or independent …

Telomeres maintain genomic integrity in normal cells, and their progressive shortening
during successive cell divisions induces chromosomal instability. In the large majority of …

Background Limitless self-renewal is one of the hallmarks of cancer and is attained by
telomere maintenance, essentially through telomerase (h TERT) activation. Transcriptional …

Human T-cell leukemia virus type 1 (HTLV-1) is the causative agent of a fatal malignancy
known as adult T-cell leukemia (ATL). One way to address the pathology of the disease lies …

Telomerase (TERT) activation is a fundamental step in tumorigenesis. By maintaining
telomere length, telomerase relieves a main barrier on cellular lifespan, enabling limitless …

As humans live longer, a central concern is to find ways to maintain their health as they age.
Immunity declines during ageing, as shown by the increased susceptibility to infection by …

Age-related macular degeneration (AMD) is a complex eye disease underlined by the death
of photoreceptors and degeneration of retinal pigment epithelium (RPE) and choriocapillaris …

The genomes of prokaryotes and eukaryotic organelles are usually circular as are most
plasmids and viral genomes. In contrast, the nuclear genomes of eukaryotes are organized …

Although nearly all mammalian species are diploid, whole-genome duplications occur in
select mammalian tissues as part of normal development. Such programmed …

Four-stranded DNA structures were structurally characterized in vitro by NMR, X-ray and
Circular Dichroism spectroscopy in detail. Among the different types of quadruplexes (i …