Pharmacotherapy of schizophrenia based on the dopamine hypothesis remains
unsatisfactory for the negative and cognitive symptoms of the disease. Enhancing N-methyl …

There are four adenosine receptors, A1, A2A, A2B and A3, together forming a defined
subgroup of G protein coupled receptors. They are well conserved and widely expressed …

The molecular basis for the known intramembrane receptor/receptor interactions among G
protein-coupled receptors was postulated to be heteromerization based on receptor subtype …

Age-related cognitive decline has been linked to a diverse set of neurobiological
mechanisms, including bidirectional changes in proteins critical for neuron function …

The purinergic signalling system, which uses purines and pyrimidines as chemical
transmitters, and purinoceptors as effectors, is deeply rooted in evolution and development …

Eighty years ago Drury & Szent-Gyorgyi described the actions of adenosine, AMP (adenylic
acid) and ATP (pyrophosphoric or diphosphoric ester of adenylic acid) on the mammalian …

In the pursuit of improved treatments for Parkinson's disease (PD), the adenosine A2A
receptor has emerged as an attractive nondopaminergic target. Based on the compelling …

Astrogliosis is a pathological hallmark of the epileptic brain. The identification of
mechanisms that link astrogliosis to neuronal dysfunction in epilepsy may provide new …

The chemokine CX3CL1 and its receptor CX3CR1 are constitutively expressed in the
nervous system. In this study, we used in vivo murine models of permanent middle cerebral …

Nutritional ketosis has been proven effective for seizure disorders and other neurological
disorders. The focus of this study was to determine the effects of ketone supplementation on …