Adenosine is well known to be released during cerebral metabolic stress and is believed to
be neuroprotective. ATP release under similar circumstances has been much less studied …

Objective The objective of the current article is to review the shared pathophysiological
mechanisms which may underlie the clinical association between headaches and sleep …

Metabolic perturbations that decrease or limit blood glucose—such as fasting or adhering to
a ketogenic diet—reduce epileptic seizures significantly. To date, the critical links between …

Neuronal communication plays an essential role in the propagation of information in the
brain and requires a precisely orchestrated connectivity between neurons. Synaptic …

The hypothesis that adenosine acting on adenosine A1 receptors (A1R) regulates several
renal functions and mediates tubuloglomerular feedback (TGF) was examined using A1R …

In addition to affecting respiration and vascular tone, deviations from normal CO 2 alter pH,
consciousness, and seizure propensity. Outside the brainstem, however, the mechanisms by …

Purinergic receptors (Rs) of the ATP/ADP, UTP/UDP (P2X, P2Y) and adenosine (A1, A2A)-
sensitive classes broadly interfere with cognitive processes both under quasi normal and …

Uric acid and purines (such as adenosine) regulate mood, sleep, activity, appetite, cognition,
memory, convulsive threshold, social interaction, drive, and impulsivity. A link between …

Behavioural assessment of mice lacking adenosine A1 receptors (A1Rs) showed reduced
activity in some phases of the light–dark cycle, reduced exploratory behaviour in the open …

Fatty liver is commonly associated with alcohol ingestion and abuse. While the molecular
pathogenesis of these fatty changes is well understood, the biochemical and …