Thymic development of unconventional T cells: how NKT cells, MAIT cells and γδ T cells emerge

DG Pellicci, HF Koay, SP Berzins - Nature Reviews Immunology, 2020 - nature.com
T cell lineages are defined by specialized functions and differential expression of surface
antigens, cytokines and transcription factors. Conventional CD4+ and CD8+ T cells are the …

Guidelines for the use of flow cytometry and cell sorting in immunological studies

A Cossarizza, HD Chang, A Radbruch… - European journal of …, 2021 - Wiley Online Library
The third edition of Flow Cytometry Guidelines provides the key aspects to consider when
performing flow cytometry experiments and includes comprehensive sections describing …

Role of MR1-driven signals and amphiregulin on the recruitment and repair function of MAIT cells during skin wound healing

A Du Halgouet, A Darbois, M Alkobtawi, M Mestdagh… - Immunity, 2023 - cell.com
Tissue repair processes maintain proper organ function following mechanical or infection-
related damage. In addition to antibacterial properties, mucosal associated invariant T …

Single-cell analysis of human MAIT cell transcriptional, functional and clonal diversity

LC Garner, A Amini, MEB FitzPatrick, MJ Lett… - Nature …, 2023 - nature.com
Mucosal-associated invariant T (MAIT) cells are innate-like T cells that recognize microbial
metabolites through a semi-invariant T cell receptor (TCR). Major questions remain …

Microbial metabolites control the thymic development of mucosal-associated invariant T cells

F Legoux, D Bellet, C Daviaud, Y El Morr, A Darbois… - Science, 2019 - science.org
How the microbiota modulate immune functions remains poorly understood. Mucosal-
associated invariant T (MAIT) cells are implicated in mucosal homeostasis and absent in …

Mucosal-associated invariant T cells promote inflammation and intestinal dysbiosis leading to metabolic dysfunction during obesity

A Toubal, B Kiaf, L Beaudoin, L Cagninacci… - Nature …, 2020 - nature.com
Obesity is associated with low-grade chronic inflammation promoting insulin-resistance and
diabetes. Gut microbiota dysbiosis is a consequence as well as a driver of obesity and …

MAIT cell development and functions: the microbial connection

F Legoux, M Salou, O Lantz - Immunity, 2020 - cell.com
Mucosal-associated invariant T (MAIT) cells are an evolutionarily conserved T cell subset,
which reacts to most bacteria through T cell receptor (TCR)-mediated recognition of …

MAIT cells in health and disease

NM Provine, P Klenerman - Annual review of immunology, 2020 - annualreviews.org
Mucosal-associated invariant T (MAIT) cells have been attracting increasing attention over
the last few years as a potent unconventional T cell subset. Three factors largely account for …

[HTML][HTML] A conserved transcriptional program for MAIT cells across mammalian evolution

H Bugaut, Y El Morr, M Mestdagh… - The Journal of …, 2024 - ncbi.nlm.nih.gov
Mucosal-associated invariant T (MAIT) cells harbor evolutionarily conserved TCRs,
suggesting important functions. As human and mouse MAIT functional programs appear …

Normalizing and denoising protein expression data from droplet-based single cell profiling

MP Mulè, AJ Martins, JS Tsang - Nature communications, 2022 - nature.com
Multimodal single-cell profiling methods that measure protein expression with oligo-
conjugated antibodies hold promise for comprehensive dissection of cellular heterogeneity …