The cystic fibrosis transmembrane conductance regulator (CFTR) is a crucial ion channel for
transport of chloride and bicarbonate anions. Functional roles of CFTR have been identified …

Patients suffering from chronic obstructive pulmonary disease (COPD) clinically manifest
airway mucus hypersecretion as sputum expectoration and cough. Evidence accumulated in …

Background: Preserved ratio impaired spirometry (PRISm) refers to decreased forced
expiratory volume in 1 s (FEV1) in the setting of preserved ratio. Little is known about the …

Background The role of airway impairment assessed by impulse oscillometry (IOS) in
patients with chronic obstructive pulmonary disease (COPD) remains unclear. Therefore …

Practical relevance: Feline inflammatory airway diseases, including (but not limited to)
asthma, chronic bronchitis and bronchiectasis, are common and incurable disorders. These …

Respiratory oscillometry is gaining global attention over traditional pulmonary function tests
for its sensitivity in detecting small airway obstructions. However, its use in clinical settings …

Introduction Small airway disease (SAD) represents a common and critical feature of
Chronic Obstructive Pulmonary Disease (COPD). Introduced in the'60s, SAD has gradually …

Isolated airway smooth muscle has been extensively investigated since 1840 to understand
the pharmacology of airway diseases. There has often been poor predictability from murine …

Abstract Background and Objective The use of small airway parameters generated by
spirometry, namely forced expiratory flow between 25% and 75% of forced vital capacity …

Background Small airways disease plays a key role in the pathogenesis of chronic
obstructive pulmonary disease (COPD) and is a major cause of obstruction; therefore, it is a …