Tumors are comprised of both cancer cells and surrounding stromal components. As an
essential part of the tumor microenvironment, the tumor stroma is highly dynamic …

Simple Summary The survival rates for patients with pancreatic adenocarcinoma are very
low. This dismal prognosis is due in part to late detection and early development of …

Pancreatic cancer is one of the common malignant tumors of the digestive system and is
known as the “king of cancers”. It is extremely difficult to diagnose at an early stage, the …

The extracellular matrix (ECM) is a vital component of the tumor microenvironment, which
interplays with stromal and tumor cells to stimulate the capacity of cancer cells to proliferate …

The tumor immune microenvironment (TIME) plays a key role in immunosuppression in
cancer, which results in tumorigenesis and tumor progression, and contributes to …

Background Pancreatic ductal adenocarcinoma (PDAC) has a complex tumor immune
microenvironment (TIME), the clinical value of which remains elusive. This study aimed to …

Mechanical forces in the tumor microenvironment (TME) are associated with tumor growth,
proliferation, and drug resistance. Strong mechanical forces in tumors alter the metabolism …

Pancreatic ductal adenocarcinoma (PDAC) tumor microenvironment (TME) consists of
multiple cell types interspersed by dense fibrous stroma. These cells communicate through …

Pancreatic Ductal Adenocarcinoma (PDAC) is projected to become the 2nd leading cause of
cancer-related deaths in the United States. Limitations in early detection and treatment …

Carcinogenesis is a multifactorial process with the input and interactions of environmental,
genetic, and metabolic factors. During cancer development, a significant remodeling of the …