[HTML][HTML] Glucocorticoid receptor gene (NR3C1) methylation processes as mediators of early adversity in stress-related disorders causality: a critical review
Early life stress (ELS) is a known risk factor for suffering psychopathology in adulthood. The
hypothalamic–pituitary–adrenal (HPA) axis has been described to be deregulated in both …
hypothalamic–pituitary–adrenal (HPA) axis has been described to be deregulated in both …
Evolution and molecular mechanisms of adaptive developmental plasticity
Aside from its selective role in filtering inter‐individual variation during evolution by natural
selection, the environment also plays an instructive role in producing variation during …
selection, the environment also plays an instructive role in producing variation during …
DNA hypermethylation associated with upregulated gene expression in prostate cancer demonstrates the diversity of epigenetic regulation
I Rauluseviciute, F Drabløs, MB Rye - BMC medical genomics, 2020 - Springer
Abstract Background Prostate cancer (PCa) has the highest incidence rates of cancers in
men in western countries. Unlike several other types of cancer, PCa has few genetic drivers …
men in western countries. Unlike several other types of cancer, PCa has few genetic drivers …
[HTML][HTML] Epigenetic regulation of astrocyte function in neuroinflammation and neurodegeneration
M Neal, JR Richardson - Biochimica et Biophysica Acta (BBA)-Molecular …, 2018 - Elsevier
Epigenetic mechanisms control various functions throughout the body, from cell fate
determination in development to immune responses and inflammation. Neuroinflammation …
determination in development to immune responses and inflammation. Neuroinflammation …
A mechanistic understanding of production instability in CHO cell lines expressing recombinant monoclonal antibodies
M Kim, PM O'Callaghan, KA Droms… - Biotechnology and …, 2011 - Wiley Online Library
One of the most significant problems in industrial bioprocessing of recombinant proteins
using engineered mammalian cells is the phenomenon of cell line instability, where a …
using engineered mammalian cells is the phenomenon of cell line instability, where a …
The importance of ncRNAs as epigenetic mechanisms in phenotypic variation and organic evolution
D Frías-Lasserre, CA Villagra - Frontiers in Microbiology, 2017 - frontiersin.org
Neo-Darwinian explanations of organic evolution have settled on mutation as the principal
factor in producing evolutionary novelty. Mechanistic characterizations have been also …
factor in producing evolutionary novelty. Mechanistic characterizations have been also …
Grid'5000: A large scale and highly reconfigurable grid experimental testbed
F Cappello, E Caron, M Dayde… - The 6th IEEE/ACM …, 2005 - ieeexplore.ieee.org
Large scale distributed systems like Grids are difficult to study only from theoretical models
and simulators. Most Grids deployed at large scale are production platforms that are …
and simulators. Most Grids deployed at large scale are production platforms that are …
Psychosocial stress and epigenetic aging
H Palma-Gudiel, L Fañanás, S Horvath… - International review of …, 2020 - Elsevier
Aging is the single most important risk factor for diseases that are currently the leading
causes of morbidity and mortality. However, there is considerable inter-individual variability …
causes of morbidity and mortality. However, there is considerable inter-individual variability …
[HTML][HTML] Epigenetic modifications: Key players in cancer heterogeneity and drug resistance
Cancer heterogeneity and drug resistance remain pivotal obstacles in effective cancer
treatment and management. One major contributor to these challenges is epigenetic …
treatment and management. One major contributor to these challenges is epigenetic …
Cervical cancer markers: epigenetics and microRNAs
V Laengsri, U Kerdpin, C Plabplueng… - Laboratory …, 2018 - academic.oup.com
Gynecologic malignant neoplasms are a severe health problem among female patients, of
which cervical cancer (CC), in particular, is a common disease leading to high mortality …
which cervical cancer (CC), in particular, is a common disease leading to high mortality …