[HTML][HTML] Glucocorticoid receptor gene (NR3C1) methylation processes as mediators of early adversity in stress-related disorders causality: a critical review

H Palma-Gudiel, A Córdova-Palomera, JC Leza… - Neuroscience & …, 2015 - Elsevier
Early life stress (ELS) is a known risk factor for suffering psychopathology in adulthood. The
hypothalamic–pituitary–adrenal (HPA) axis has been described to be deregulated in both …

Evolution and molecular mechanisms of adaptive developmental plasticity

P Beldade, ARA Mateus, RA Keller - Molecular ecology, 2011 - Wiley Online Library
Aside from its selective role in filtering inter‐individual variation during evolution by natural
selection, the environment also plays an instructive role in producing variation during …

DNA hypermethylation associated with upregulated gene expression in prostate cancer demonstrates the diversity of epigenetic regulation

I Rauluseviciute, F Drabløs, MB Rye - BMC medical genomics, 2020 - Springer
Abstract Background Prostate cancer (PCa) has the highest incidence rates of cancers in
men in western countries. Unlike several other types of cancer, PCa has few genetic drivers …

[HTML][HTML] Epigenetic regulation of astrocyte function in neuroinflammation and neurodegeneration

M Neal, JR Richardson - Biochimica et Biophysica Acta (BBA)-Molecular …, 2018 - Elsevier
Epigenetic mechanisms control various functions throughout the body, from cell fate
determination in development to immune responses and inflammation. Neuroinflammation …

A mechanistic understanding of production instability in CHO cell lines expressing recombinant monoclonal antibodies

M Kim, PM O'Callaghan, KA Droms… - Biotechnology and …, 2011 - Wiley Online Library
One of the most significant problems in industrial bioprocessing of recombinant proteins
using engineered mammalian cells is the phenomenon of cell line instability, where a …

The importance of ncRNAs as epigenetic mechanisms in phenotypic variation and organic evolution

D Frías-Lasserre, CA Villagra - Frontiers in Microbiology, 2017 - frontiersin.org
Neo-Darwinian explanations of organic evolution have settled on mutation as the principal
factor in producing evolutionary novelty. Mechanistic characterizations have been also …

Grid'5000: A large scale and highly reconfigurable grid experimental testbed

F Cappello, E Caron, M Dayde… - The 6th IEEE/ACM …, 2005 - ieeexplore.ieee.org
Large scale distributed systems like Grids are difficult to study only from theoretical models
and simulators. Most Grids deployed at large scale are production platforms that are …

Psychosocial stress and epigenetic aging

H Palma-Gudiel, L Fañanás, S Horvath… - International review of …, 2020 - Elsevier
Aging is the single most important risk factor for diseases that are currently the leading
causes of morbidity and mortality. However, there is considerable inter-individual variability …

[HTML][HTML] Epigenetic modifications: Key players in cancer heterogeneity and drug resistance

HQ Sadida, A Abdulla, S Al Marzooqi, S Hashem… - Translational …, 2024 - Elsevier
Cancer heterogeneity and drug resistance remain pivotal obstacles in effective cancer
treatment and management. One major contributor to these challenges is epigenetic …

Cervical cancer markers: epigenetics and microRNAs

V Laengsri, U Kerdpin, C Plabplueng… - Laboratory …, 2018 - academic.oup.com
Gynecologic malignant neoplasms are a severe health problem among female patients, of
which cervical cancer (CC), in particular, is a common disease leading to high mortality …