Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that is characterized
by a defect in immune tolerance and exacerbated by both the innate and adaptive arms of …

Objective To assess dose-response effects of the anti-CD20 monoclonal antibody
ofatumumab on efficacy and safety outcomes in a phase 2b double-blind study of relapsing …

B cells are central pathogenic players in systemic lupus erythematosus and multiple other
autoimmune diseases through antibody production as well as antibody independent …

The efficacy of B cell depletion therapies in diseases such as nephrotic syndrome and
rheumatoid arthritis suggests a broader role in B cells in human disease than previously …

We evaluated micro (mi) RNA-mediated regulation of BAFF expression in fibroblasts using
two concomitant models:(i) synovial fibroblasts (FLS) isolated from healthy controls (N) or …

The ubiquitin‐proteasome system is the major intracellular molecular machinery for protein
degradation and maintenance of protein homeostasis in most human cells. As ubiquitin …

IL-17-producing B cells combat parasites | Nature Immunology Skip to main content Thank you
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Purpose B lymphocyte induced maturation protein 1 (Blimp1) is a transcription factor that is
critical for differentiation and antibody production in plasma cells. In order to understand the …

The reliable assessment of monoclonal antibody (mAb) affinity against membrane proteins
in vivo is a major issue in the development of cancer therapeutics. We describe here a …

Antibodies were the first elements of the immune system to be identified. They are antigen-
reactive proteins present in an immune serum, called antiserum, and obtained after …