Epigenetics regulates gene expression and has been confirmed to play a critical role in a
variety of metabolic diseases, such as diabetes, obesity, non-alcoholic fatty liver disease …

Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

Diabetic kidney disease (DKD) is a severe and common complication and affects a quarter
of patients with type 2 diabetes mellitus (T2DM). Oxidative stress and inflammation related to …

For many years, it has been clear that a Western diet rich in saturated fats and sugars
promotes an inflammatory environment predisposing a person to chronic cardiometabolic …

Post-translational modifications (PTMs) endow proteins with new properties to respond to
environmental changes or growth needs. With the development of advanced proteomics …

Abstract β-hydroxybutyrate (β-HB), the most abundant ketone body, is produced primarily in
the liver and acts as a substitute energy fuel to provide energy to extrahepatic tissues in the …

Ketone bodies (KBs), such as acetoacetate and β-hydroxybutyrate, serve as crucial
alternative energy sources during glucose deficiency. KBs, generated through ketogenesis …

Histones undergo a plethora of post-translational modifications (PTMs) that regulate
nucleosome and chromatin dynamics and thus dictate cell fate. Several evidences suggest …

Ketogenic metabolic therapy (KMT) is a medical nutrition therapy to address certain health
and disease conditions. It is increasingly used for many non-communicable diseases that …

Overactivation of the NLRP3 inflammasome is implicated in chronic low-grade inflammation
associated with various disease states, including obesity, type 2 diabetes, atherosclerosis …