Despite significant improvements of new treatment options, cancer continues to represent as
one of the most common and fatal disease. The EGFR signaling pathway is considered as a …

Pyrazole derivatives, as a class of heterocyclic compounds, possess unique chemical
structures that confer them with a broad spectrum of pharmacological activities. They have …

Currently, the humanity is in a fierce battle against various health-related challenges
especially those associated with human malignancies. This created the urge to develop …

This study was focused on the synthesis of new pyrimidines 4a, b, 5a, b and pyrazoles 6a, b
as ATP mimicking tyrosine kinase inhibitors of the epidermal growth factor receptor (EGFR) …

In this article, we continued our previous effort to develop new selective anticancer
candidates based on the basic pharmacophoric requirements of both EGFR and VEGFR-2 …

New series of thiazole and imidazo [2, 1-b] thiazole derivatives were synthesized and tested
for their in vitro anticancer activity. Compounds 27, 34, 39 and 42–44 showed the best …

Targeting the epidermal growth factor receptors (EGFRs) with small inhibitor molecules has
been validated as a potential therapeutic strategy in cancer therapy. Pyrazolo [3, 4‐d] …

Multicomponent reactions (MCRs) have been gaining significance and attention over the
past decade because of their ability to furnish complex products by using readily available …

The fusion of pyrazole scaffold with other skeletons creates a class of attractive molecules,
demonstrating significant biological and chemical potentiality in the development of …

Novel series of diazepam bearing sulfonamide moieties 5 af and 7 ac were designed,
synthesized and evaluated for anticancer activity against HepG2, HCT-116 and MCF-7 cell …