In the past decade, membraneless assemblies known as biomolecular condensates have
been reported to play key roles in many cellular functions by compartmentalizing specific …

Abstract Treatment outcomes for pediatric patients with acute myeloid leukemia (AML) have
continued to lag behind outcomes reported for children with acute lymphoblastic leukemia …

Cancer-associated chromosomal rearrangements can result in the expression of numerous
pathogenic fusion proteins. The mechanisms by which fusion proteins contribute to …

NUP98 fusion oncoproteins (FO) are drivers in pediatric leukemias and many transform
hematopoietic cells. Most NUP98 FOs harbor an intrinsically disordered region from NUP98 …

Translocations involving the NUP98 gene produce NUP98-fusion proteins and are
associated with a poor prognosis in acute myeloid leukemia (AML). MLL1 is a molecular …

NUP98 fusions comprise a family of rare recurrent alterations in AML, associated with
adverse outcomes. In order to define the underlying biology and clinical implications of this …

NUP98 and NUP214 form chimeric fusion proteins that assemble into phase-separated
nuclear bodies containing CRM1, a nuclear export receptor. However, these nuclear bodies' …

Proper subcellular localization is crucial for the functioning of biomacromolecules, including
proteins and RNAs. Nuclear transport is a fundamental cellular process that regulates the …

Fusion oncoproteins (FOs) resulting from in-frame chromosomal translocations are
associated with many aggressive cancers with poor patient outcomes. Several FOs are now …

Studies have revealed key genomic aberrations in pediatric acute myeloid leukemia (AML)
based on Western populations. It is unknown to what extent the current genomic findings …