The vinca alkaloids have played an important role in the chemotherapy of malignant disease
for many years. As is often the case with therapeutic agents, their discovery was somewhat …

PURPOSE The feasibility of administering vinorelbine (Navelbine, Burroughs Wellcome Co,
Research Triangle Park, NC), a semisynthetic vinca alkaloid with broad activity, as a liquid …

Aims a) To characterize the pharmacokinetics of intravenous vinorelbine, b) to use a
population analysis for the identification of patient covariates that might appreciably …

Prolonged vinorelbine exposure is correlated with improved antineoplastic effects, as
evidenced by increased response rate in patients receiving continuous infusion. The …

Tubulins are cytoskeleton components in all eukaryotic cells and play crucial roles in various
cellular activities by polymerizing into dynamic microtubules. A subpopulation of tubulin has …

Vinorelbine tartrate (VNR), a semi-synthetic vinca alkaloid acquired from vinblastine, has
extensively been used as an anticancer agent. However, VNR-induced oxidative damage …

Non-small cell lung cancer (NSCLC) is a leading cause of cancer death in industrialised
countries, with an overall 5-year survival rate of less than 10%. Good patient performance …

The effects of food and divided dosing on the bioavailability of a liquid-filled gelatin capsule
formulation of vinorelbine (Navelbine), a semisynthetic vinca alkaloid with broad clinical …

A total of 32 patients with advanced non-small-cell lung cancer were treated with carboplatin
(350 mg/m 2, day 1) and vinorelbine (days 1 and 8) every 28 days. A response rate of …

Aims and background The aim of the study was to assess the activity and toxicity of the
vinorelbine-carboplatin combination in advanced adenocarcinoma or large-cell carcinoma …