Chronic immune activation in TB/HIV co-infection
HIV co-infection is the most critical risk factor for the reactivation of latent tuberculosis (TB)
infection (LTBI). While CD4+ T cell depletion has been considered the major cause of HIV …
infection (LTBI). While CD4+ T cell depletion has been considered the major cause of HIV …
[HTML][HTML] COVID-19 and HIV-associated immune reconstitution inflammatory syndrome: emergence of pathogen-specific immune responses adding fuel to the fire
N Seddiki, M French - Frontiers in Immunology, 2021 - frontiersin.org
Both coronavirus disease 2019 (COVID-19) and mycobacterial immune reconstitution
inflammatory syndrome (IRIS) in patients with HIV-1 infection result from immunopathology …
inflammatory syndrome (IRIS) in patients with HIV-1 infection result from immunopathology …
[HTML][HTML] Pulmonary Mycobacterium tuberculosis control associates with CXCR3-and CCR6-expressing antigen-specific Th1 and Th17 cell recruitment
U Shanmugasundaram, AN Bucsan, SR Ganatra… - JCI insight, 2020 - ncbi.nlm.nih.gov
Mycobacterium tuberculosis–specific (M. tuberculosis–specific) T cell responses associated
with immune control during asymptomatic latent tuberculosis infection (LTBI) remain poorly …
with immune control during asymptomatic latent tuberculosis infection (LTBI) remain poorly …
[HTML][HTML] ZEB1 promotes pathogenic Th1 and Th17 cell differentiation in multiple sclerosis
Summary Inappropriate CD4+ T helper (Th) differentiation can compromise host immunity or
promote autoimmune disease. To identify disease-relevant regulators of T cell fate, we …
promote autoimmune disease. To identify disease-relevant regulators of T cell fate, we …
[HTML][HTML] Type 2 and type 17 effector cells are increased in the duodenal mucosa but not peripheral blood of patients with functional dyspepsia
GL Burns, JK Bruce, K Minahan, A Mathe… - Frontiers in …, 2023 - frontiersin.org
Background Functional dyspepsia is characterised by chronic symptoms of post-prandial
distress or epigastric pain not associated with defined structural pathology. Increased …
distress or epigastric pain not associated with defined structural pathology. Increased …
[HTML][HTML] Antiretroviral therapy does not reduce tuberculosis reactivation in a tuberculosis-HIV coinfection model
SR Ganatra, AN Bucşan, X Alvarez… - The Journal of …, 2020 - Am Soc Clin Investig
While the advent of combination antiretroviral therapy (ART) has significantly improved
survival, tuberculosis (TB) remains the leading cause of death in the HIV-infected …
survival, tuberculosis (TB) remains the leading cause of death in the HIV-infected …
[HTML][HTML] Multi-parameter flow cytometry immunophenotyping distinguishes different stages of tuberculosis infection
O Estévez, L Anibarro, E Garet, A Martínez, A Pena… - Journal of Infection, 2020 - Elsevier
Objectives To identify new potential host biomarkers in blood to discriminate between active
TB patients, uninfected (NoTBI) and latently infected contacts (LTBI). Methods A blood cell …
TB patients, uninfected (NoTBI) and latently infected contacts (LTBI). Methods A blood cell …
Chemokine receptor CXCR3 is required for lethal brain pathology but not pathogen clearance during cryptococcal meningoencephalitis
Cryptococcal meningoencephalitis (CM) is the major cause of infection-related neurological
death, typically seen in immunocompromised patients. However, T cell–driven inflammatory …
death, typically seen in immunocompromised patients. However, T cell–driven inflammatory …
[HTML][HTML] Antiretroviral therapy timing impacts latent tuberculosis infection reactivation in a Mycobacterium tuberculosis/SIV coinfection model
R Sharan, SR Ganatra, AN Bucsan… - The Journal of …, 2022 - Am Soc Clin Investig
Studies using the nonhuman primate model of Mycobacterium tuberculosis/simian
immunodeficiency virus coinfection have revealed protective CD4+ T cell–independent …
immunodeficiency virus coinfection have revealed protective CD4+ T cell–independent …
[HTML][HTML] Dynamics of T-lymphocyte activation related to paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome in persons with advanced …
R Tibúrcio, B Barreto-Duarte, G Naredren… - Frontiers in …, 2021 - frontiersin.org
Most persons living with HIV (PLWH) experience a significant restoration of their immunity
associated with successful inhibition of viral replication after antiretroviral therapy (ART) …
associated with successful inhibition of viral replication after antiretroviral therapy (ART) …